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ProteomicsSON and SRRM2 form nuclear speckles in human cells
The nucleus of higher eukaryotes is a highly compartmentalized and dynamic organelle consisting of several biological condensates that regulate gene expression at multiple levels. First reported more than 100 years ago by Ramón y Cajal, nuclear speckles (NS) are among the most prominent of such cond...
ORGANISM(S): Homo sapiens (Human) 
2020-10-26 | PXD021814 | Pride
Srrm2  nuclear speckles 
TranscriptomicsRNA-seq of mouse ES cells depleted of MOF, MSL1, MSL2 or KANSL3
We have studied the regulatory potential of MYST1-(MOF)-containing MSL and NSL complexes in mouse embryonic stem cells (ESCs) and neuronal progenitors. We find that both complexes influence transcription by binding to promoters as well as TSS-distal enhancer regions. In contrast to flies, the MSL co...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-57698 | biostudies-arrayexpress
GenomicsChIP-seq of MOF, MSL and NSL complex members in mouse ES cells and neuronal progenitors
We assessed the genome-wide binding of the histone acetylase MOF and members of its two associated complexes, the male-specific lethal and the non-specific lethal complex (MSL, NSL). We generated ChIP-seq profiles for MOF, MSL1, MSL2, KANSL3, and MCRS1 from mouse embryonic stem cells and neuronal pr...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-51746 | biostudies-arrayexpress
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