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ProteomicsAKT and AMPK site-specific phosphorylation on TBC1D4 biological activity
TBC1D4 is a 160 kDa multi-domain containing RabGAP (Rab GTPase-activating protein) and a downstream target of the insulin and contraction-activated kinases AKT and AMPK. While phosphorylation of TBC1D4 has been linked to GLUT4 translocation from storage vesicles (GSVs) to the cell surface, its impac...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024645 | Pride
Lc-msms Partial digest Tbc1d4 
ProteomicsThe effect of AKT and AMPK site-specific phosphorylation on TBC1D4 biological activity
TBC1D4 is a 160 kDa multi-domain containing RabGAP (Rab GTPase-activating protein) and a downstream target of the insulin and contraction-activated kinases AKT and AMPK. While phosphorylation of TBC1D4 has been linked to GLUT4 translocation from storage vesicles (GSVs) to the cell surface, its impac...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024621 | Pride
Lc-msms Tbc1d4 Protein phosphorylation 
TranscriptomicsCytokines dominate the secretome of primary human myotubes in an in vitro exercise model
Muscle contraction during exercise is the major stimulus for the release of peptides and proteins (myokines) that are supposed to take part in the benefical adaptation to exercise. We hypothesize that application of an in vitro exercise stimulus as electric pulse stimulation (EPS) to human myotubes ...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-44051 | biostudies-arrayexpress
ProteomicsTemporal phosphoproteomics reveals circuitry of phased propagation in insulin signaling
Insulin is a pleiotropic hormone that elicits its metabolic and mitogenic actions through numerous rapid and reversible protein phosphorylations. The temporal regulation of insulin’s intracellular signaling cascade is highly complex and insufficiently understood. We conducted a time-resolved analysi...
ORGANISM(S): Homo sapiens (Human) 
2025-02-13 | PXD058852 | Pride
Phosphoproteomics Donor variability Insulin signaling Skeletal muscle Mrna splicing 
UnknownGlobal, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
Not available
S-EPMC10356620 | biostudies-literature
UnknownTrends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021.
Not available
S-EPMC11306195 | biostudies-literature
UnknownThe global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023.
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S-EPMC12687902 | biostudies-literature
UnknownGlobal, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990-2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021.
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S-EPMC12018300 | biostudies-literature
UnknownGlobal, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021.
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S-EPMC12557468 | biostudies-literature
UnknownBurnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey.
Not available
S-EPMC10810224 | biostudies-literature
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