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ProteomicsThe effect of AKT and AMPK site-specific phosphorylation on TBC1D4 biological activity
TBC1D4 is a 160 kDa multi-domain containing RabGAP (Rab GTPase-activating protein) and a downstream target of the insulin and contraction-activated kinases AKT and AMPK. While phosphorylation of TBC1D4 has been linked to GLUT4 translocation from storage vesicles (GSVs) to the cell surface, its impac...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024621 | Pride
Lc-msms Tbc1d4 Protein phosphorylation 
TranscriptomicsRole of TBC1D4 in mouse kidneys: Identification of compensatory mechanisms in the DCT of TBC1D4-deficient mice
In vitro studies identified TBC1D4 as an regulator of renal ion and water transporting proteins. However, TBC1D4-deficient mice did not show a defective renal salt and water homeostasis. With microarray analysis we aimed to decipher compensatory mechanisms in TBC1D4-deficient mice which might mask t...
ORGANISM(S): Mus musculus 
2015-04-10 | E-GEOD-67701 | biostudies-arrayexpress
ProteomicsAKT and AMPK site-specific phosphorylation on TBC1D4 biological activity
TBC1D4 is a 160 kDa multi-domain containing RabGAP (Rab GTPase-activating protein) and a downstream target of the insulin and contraction-activated kinases AKT and AMPK. While phosphorylation of TBC1D4 has been linked to GLUT4 translocation from storage vesicles (GSVs) to the cell surface, its impac...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024645 | Pride
Lc-msms Partial digest Tbc1d4 
ProteomicsMass spectrometry-based analysis of the TBC1D4 interactome in human skeletal muscle
Insulin-stimulated muscle glucose uptake is a key process to alleviate hyperglycemia. This process depends on the redistribution of glucose transporters to the muscle surface membrane following phosphorylation of TBC1D1 and TBC1D4. Genetic evidence from a TBC1D4 loss-of-function mutation in human sk...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-03-01 | PXD026225 | Pride
Muscle Tbc1d4 Diabetes Insulin Interactome Lcms 
TranscriptomicsRole of TBC1D4 in mouse kidneys: Identification of compensatory mechanisms in the DCT of TBC1D4-deficient mice
In vitro studies identified TBC1D4 as an regulator of renal ion and water transporting proteins. However, TBC1D4-deficient mice did not show a defective renal salt and water homeostasis. With microarray analysis we aimed to decipher compensatory mechanisms in TBC1D4-deficient mice which might mask t...
ORGANISM(S): Mus musculus 
2015-04-10 | GSE67701 | GEO
GenomicsMus musculus
Role of TBC1D4 in mouse kidneys: Identification of compensatory mechanisms in the DCT of TBC1D4-deficient mice
PRJNA280721 | ENA
UnknownTBC1D4 antagonizes RAB2A-mediated autophagic and endocytic pathways.
Not available
S-EPMC11572321 | biostudies-literature
UnknownIllumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle.
Not available
S-EPMC9074744 | biostudies-literature
ProteomicsSkeletal muscle proteome analysis of Inuit homozygous carriers of the common Greenlandic TBC1D4 p.Arg684Ter variant
In the Greenlandic Inuit population, 17% are carriers of a nonsense TBC1D4 p.Arg684Ter variant. Homozygous variant carriers have impaired glucose tolerance and a 10-fold increased risk of type 2 diabetes. Here, we illuminate the consequences of lacking this muscle-specific long isoform of TBC1D4 dur...
ORGANISM(S): Homo sapiens (Human) 
2024-10-26 | PXD045301 | Pride
Lc-msms Skeletal muscle Muscle Proteome 
ProteomicsWNK1-specific phosphorylation sites in TBC1D1 and TBC1D4 modulate cell surface expression of GLUT1
Glucose uptake by mammalian cells is a key mechanism to maintain cell and tissue homeostasis and relies mostly on plasma membrane-localized glucose transporter proteins (GLUTs). Two main cellular mechanisms regulate GLUT proteins in the cell: first, expression of GLUT genes is under dynamic transcri...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD016218 | Pride
Human Phosphorylation 
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