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The most preclinical used in vivo model to study lung fibrosis is the bleomycin-induced lung fibrosis model in 2-3-month-old mice. Although this model resembles key aspects of idiopathic pulmonary fibrosis (IPF), there are limitations in its predictability for the human disease. One of the main diff...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-10 | PXD026222 | Pride
ER-associated degradation (ERAD) is an evolutionarily-conserved quality control mechanism where misfolded proteins are removed from the endoplasmic reticulum (ER) and degraded by the ubiquitin-proteasome system. While many ERAD-mediating proteins have been identified, it is unknown how they are spat...
ORGANISM(S): Chlamydomonas reinhardtii 
2020-05-26 | PXD009375 | Pride
We performed phosphorylation site mapping on of budding yeast Atg13 applying a quantitative mass spectrometry-based proteomics approach based on stable isotope labeling with amino acids in cell culture (SILAC). We determined changes in the Atg13 phosphorylation pattern in response of inhibition of k...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-01-20 | PXD028461 | Pride
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