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TranscriptomicsMicroRNA analysis unravels the molecular basis of bleomycin induced lung fibrosis in mouse
The molecular mechanisms of lung injury and fibrosis are incompletely understood. microRNAs (miRNAs) are crucial biological regulators by suppression of their target genes and are involved in a variety of pathophysiologic processes. To gain insight into miRNAs in the regulation of lung fibrosis, tot...
ORGANISM(S): Mus musculus 
2012-04-12 | E-GEOD-24323 | biostudies-arrayexpress
TranscriptomicsBleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: A model for “active” disease.
Genomic profiling of bleomycin- and saline-treated mice across 7 timepoints (1, 2, 7, 14, 21, 28, 35 days post treatment) was carried out in C57BL6/J mice to determine the phases of response to bleomycin treatment which correspond to onset of active pulmonary fibrosis. Temporal genomic characterizat...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-40151 | biostudies-arrayexpress
TranscriptomicsSCGB3A2 suppresses bleomycin-induced pulmonary fibrosis through activation of STAT1 and up-regulation of SMAD7
We report for the first time that secretoglobin (SCGB) 3A2, a novel cytokine-like molecule, predominantly expressed in pulmonary airways epithelium, drastically reduced the severity of lung fibrosis using bleomycin-induced mouse model. DNA microarrays were performed using RNAs isolated from mouse lu...
ORGANISM(S): Mus musculus 
2011-04-30 | E-GEOD-21560 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of lung fibroblasts in bleomycin-induced pulmonary fibrosis
We conducted fibroblast-specific transcriptome analysis by next generation sequencing in order to investigate qualitative change and activation signatures of lung fibroblasts in bleomycin-induced pulmonary fibrosis. Lung fibroblasts were identified by using reporter mice of collagen-α2(I), in which ...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-42564 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse lung treated with saline or bleomycin
Lung fibrosis represents the final common pathway of a variety of lung injuries, and it is characterized, independently of etiology, by the expansion of the fibroblast/myofibroblast population and by the abnormal accumulation of extracellular matrix (ECM) replacing normal functional parenchyma. In g...
ORGANISM(S): Mus musculus 
2013-03-11 | E-GEOD-42301 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of right lungs from C57BL/6J, A/J and C3H/HeJ mice following bleomcyin exposure to characterize strain dependent pulmonary bleomycin response.
right lung gene expression of C57BL/6J, A/J and C3H/HeJ mice following bleomcyin exposure. Keywords = mouse, lung, bleomycin, strain differences
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2640 | biostudies-arrayexpress
TranscriptomicsCollagen Dynamics and Transcriptional Profiling in Bleomycin-induced Pulmonary Fibrosis
Collagen deposition is a key process during idiopathic pulmonary fibrosis (IPF); however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen...
ORGANISM(S): Mus musculus 
2013-05-26 | E-GEOD-37635 | biostudies-arrayexpress
TranscriptomicsDrop-seq analysis of bleomycin-treated and control mouse lung single-cell suspensions
Cell suspensions were prepared from mouse lungs dissociated at baseline or 14 days after intratracheal bleomycin injury, and single cell mRNA-seq libraries were generated with Drop-seq.
ORGANISM(S): Mus musculus 
2018-10-25 | E-MTAB-7142 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of mouse lung during the fibrotic phase of the response to bleomycin
Wildtype mice were given saline or bleomycin by oropharyngeal instillation. After 14 days, during the fibrotic phase of the response, lungs were dissected and total RNA was extracted and used for gene expression profiling. The aim was to identify those genes regulated during the development of fibro...
ORGANISM(S): Mus musculus 
2009-07-07 | E-GEOD-16846 | biostudies-arrayexpress
TranscriptomicsTranslation value of the bleomycin rat model for the treatment of patients with Idiopathic Pulmonary Fibrosis (IPF)
Intratracheal application of bleomycin is known to induce inflammatory and fibrotic reactions in the lung within a short period of time and histological features include infiltration of inflammatory cells, collagen deposition and obliteration of alveolar spaces. Because some of these features are fo...
ORGANISM(S): Rattus norvegicus 
2014-10-28 | E-GEOD-48455 | biostudies-arrayexpress
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