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ProteomicsThe C-terminal end of engineered albumin variants and fusion proteins after exposure to carboxypeptidase A
Albumin has a long plasma half-life due to engagement of the neonatal Fc receptor (FcRn), which prevents intracellular degradation. However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-life from 2...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-19 | PXD063561 | Pride
Albumin engineering Carboxypeptidase a The neonatal fc receptor (fcrn) Albumin-fusion proteins 
TranscriptomicsAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stro...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-9004 | biostudies-arrayexpress
ProteomicsMass spectrometric analysis of fluorophore labeled albumins
A genetic engineering strategy for editing near-infrared-II fluorophores. The labeled albumin proteins were digested using suspension trapping (STrap) approach with in-house packed glass fiber filters. The LC-MS/MS analysis was performed on a nanoLC-Q Exactive MS system. The protein identification w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-07 | MSV000087386 | MassIVE
ProteomicsOilseed protein isolates as albumin alternatives for muscle cell culture media
The development of cost-effective serum-free media is essential for the development of cell-cultured meat technologies. While some effective media have been developed for relevant cells (e.g., bovine muscle stem cells), these rely on costly recombinant albumin which is too expensive for a scalable s...
ORGANISM(S): Glycine max Gossypium hirsutum Brassica napus (Rape) 
2023-03-25 | PXD036518 | Pride
Rapeseed protein isolate Serum-free cell culture Culture media Soybean protein isolate Albumin Cultured meat Cottonseed protein isolate 
GenomicsAlbumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis
Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis
PRJNA977646 | ENA
UnknownA novel albumin-based tissue scaffold for autogenic tissue engineering applications.
Not available
S-EPMC4102902 | biostudies-literature
UnknownThe albumin-binding domain as a scaffold for protein engineering.
Not available
S-EPMC3962080 | biostudies-literature
UnknownEngineering bispecificity into a single albumin-binding domain.
Not available
S-EPMC3185003 | biostudies-literature
MetabolomicsImpact of Diabetic Stress Conditions on Renal Cell Metabolome
Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria. Subsequently, albuminuria can deteriorate the ...
2019-10-08 | MTBLS1093 | MetaboLights
ProteomicsQuantification of oxidative modification of mouse serum albumin by MRM-HR
After a week of acclimatization, 8-week-old mice were randomly divided into 4 groups consisting of more than 8 mice per group, and subjected to varying total body irradiation (TBI) doses of 0, 0.5, 1 or 3 Gy of X-rays (150 kVp, 20 mA, 0.5-mm aluminum and 0.3-mm copper filters) at a dose rate of 1.0 ...
ORGANISM(S): Mus Musculus (mouse) 
2022-05-12 | PXD025949 | JPOST Repository
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