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GenomicsAlbumin-mediated Delivery of Therapeutic Peptides for Pancreatic Cancer Therapy
Albumin-mediated Delivery of Therapeutic Peptides for Pancreatic Cancer Therapy
PRJNA629118 | ENA
ProteomicsQuantification of glycated human serum albumin peptides
Human serum albumin is the most abundant plasma protein with a large number of lysine and arginine residues. Hence, it is highly susceptible to glycation in vivo. In hyperglycemic conditions, such as diabetes, the level of HSA glycation increases. Here we quantified glycated HSA peptides in a subjec...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040028 | Pride
Glycation Mass spectrometry Human serum albumin Hba1c Plasma Microalbuminuria Kidney Homo sapiens 
ProteomicsDefining albumin as a glycoprotein with multiple N-linked glycosylation sites
Background Plasma proteins can be modified by addition of sugar residues by non-enzymatic glycation as well as glycosylation. While glycation is a hallmark of hyperglycemia, glycosylation is a complex, enzyme-catalyzed post-translational modification by heterogeneous sugar chains and is present on ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) 
2024-06-16 | PXD047863 | Pride
Microheterogeneity Glycoproteomics Novel glycosylation site Hsa Human serum albumin Bsa 
ProteomicsDiscovery and validation of glucose-sensitive peptides from human serum albumin as the candidate peptide biomarkers for diagnosis of type 2 diabetes mellitus
Glycation albumin(GA) has emerged as a biomarker for diagnosing prediabetes and diabetes, which is shorter than the "gold standard" reflection period of blood glucose detection. However, the GA response is the global glycation rate of albumin, individual amino acid residues might be sensitive indica...
ORGANISM(S): Homo Sapiens 
2022-12-13 | PXD038794 |
ProteomicsQuantification of isoaspartate levels in human serum albumin of blood samples
We measured the isoaspartate levels in human serum albumin of blood samples from 20 patients with Alzheimer's disease and 20 healthy controls.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027563 | Pride
Mass spectrometry Isoaspartate Human serum albumin Alzheimer's disease 
TranscriptomicsAlbumin-mediated Delivery of Therapeutic Peptides for Pancreatic Cancer Therapy
Bioactive peptides are promising agents for therapeutic applications, however their small size results in poor stability, low bioavailability and rapid renal clearance, so its widespread use is limited. To address these issues, fusing or conjugating peptides to suitable molecular scaffolds is requir...
ORGANISM(S): Homo sapiens 
2020-12-23 | GSE149557 | GEO
ProteomicsA comparative study of synthetic winged peptides for absolute protein quantification
A proper internal standard choice is critical for accurate, precise, and reproducible mass spectrometry-based proteomics assays. Synthetic isotopically labeled (SIL) proteins are currently considered the gold standard. However, they are costly and challenging to obtain. An alternative approach uses ...
ORGANISM(S): Homo Sapiens 
2021-08-17 | PXD027985 | panorama
ProteomicsThe C-terminal end of engineered albumin variants and fusion proteins after exposure to carboxypeptidase A
Albumin has a long plasma half-life due to engagement of the neonatal Fc receptor (FcRn), which prevents intracellular degradation. However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-life from 2...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-19 | PXD063561 | Pride
Albumin engineering Carboxypeptidase a The neonatal fc receptor (fcrn) Albumin-fusion proteins 
UnknownDetermination of the affinity constants for phage display albumin-binding peptides.
Not available
S-EPMC10215749 | biostudies-literature
ProteomicsOilseed protein isolates as albumin alternatives for muscle cell culture media
The development of cost-effective serum-free media is essential for the development of cell-cultured meat technologies. While some effective media have been developed for relevant cells (e.g., bovine muscle stem cells), these rely on costly recombinant albumin which is too expensive for a scalable s...
ORGANISM(S): Glycine max Gossypium hirsutum Brassica napus (Rape) 
2023-03-25 | PXD036518 | Pride
Rapeseed protein isolate Serum-free cell culture Culture media Soybean protein isolate Albumin Cultured meat Cottonseed protein isolate 
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