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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
TranscriptomicsExpression data from hyperplastic polyps and normal colonic mucosa from patients with familial and sporadic HPPS
Expression data from hyperplastic polyps and normal colonic mucosa from patients with familial and sporadic hyperplastic polyposis syndrome (HPPS). We aim to characterize at a molecular level a cohort of hyperplastic lesions from HPPS patients with and without family history. RNA from hyperplastic p...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-19963 | biostudies-arrayexpress
ProteomicsModelling Premature Cardiac Aging with Induced Pluripotent Stem Cells From a Hutchinson-Gilford Progeria Syndrome Patient
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder that causes accelerated aging and a high risk of cardiovascular complications. However, the underlying mechanisms of cardiac complications of this syndrome are not fully understood. This study modeled HGPS using cardiomyocytes (C...
ORGANISM(S): Homo sapiens (Human) 
2022-11-10 | PXD036557 | Pride
Progeria Proteomics Ips 
TranscriptomicsTranscription profiling of Plasmodium berghei-infected hepatocytes at different times post-infection
Using in vitro models, total RNA was extracted from Plasmodium berghei infected hepatocytes at different time points (6,12,18,24 hours post-infection) and hybridized with Affymetrix microarrays. These genes are candidate for functional analysis, and we aim to use different tools to manipulate their ...
ORGANISM(S): Plasmodium berghei 
2007-09-15 | E-MEXP-667 | biostudies-arrayexpress
UnknownModelling premature cardiac aging with induced pluripotent stem cells from a hutchinson-gilford Progeria Syndrome patient.
Not available
S-EPMC9726722 | biostudies-literature
UnknownDNA Methylation Signature for EZH2 Functionally Classifies Sequence Variants in Three PRC2 Complex Genes.
Not available
S-EPMC7212265 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Not available
S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
Not available
S-EPMC8652887 | biostudies-literature
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