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TranscriptomicsAML1/ETO binding pattern on human promoters
Approximately 20% of Acute Myelogenous Leukemia (AML) cases carry the t(8;21) translocation, which involves the AML1 and ETO genes, and express the resulting AML1/ETO fusion protein that functions as a transcriptional repressor by recruiting NCoR/SMRT/HDAC complexes to DNA. We used microarrays to id...
ORGANISM(S): Homo sapiens 
2008-12-21 | E-GEOD-10531 | biostudies-arrayexpress
TranscriptomicsAnalysis of expression levels of genes on chromosome 19 in U937 cells expressing AML1/ETO
Approximately 20% of Acute Myelogenous Leukemia (AML) cases carry the t(8;21) translocation, which involves the AML1 and ETO genes, and express the resulting AML1/ETO fusion protein that functions as a transcriptional repressor by recruiting NCoR/SMRT/HDAC complexes to DNA. We used ChIP-chip to iden...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10579 | biostudies-arrayexpress
TranscriptomicsAML1/ETO, AML1, and HEB binding patterns on chromosme 19
Approximately 20% of Acute Myelogenous Leukemia (AML) cases carry the t(8;21) translocation, which involves the AML1 and ETO genes, and express the resulting AML1/ETO fusion protein that functions as a transcriptional repressor by recruiting NCoR/SMRT/HDAC complexes to DNA. We used ChIP-chip to iden...
ORGANISM(S): Homo sapiens 
2008-11-27 | E-GEOD-10578 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human osteosarcoma U2OS cell line conditionally expressing HA-tagged PRDM5
PRDM5 is a recently identified member of the PRDM family of proteins, which functions as a transcriptional repressor by recruiting histone methyltransferase G9A to DNA, and behaves as a putative tumor suppressor in different types of cancer. We investigated PRDM5 function by identifying its target g...
ORGANISM(S): Homo sapiens 
2009-01-31 | E-GEOD-10580 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of blasts from three APL patients expressing PML/RAR before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours
Gene expression profiles in blasts from three APL patients expressing PML/RAR were assessed before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours. We then studied a U937 clone conditionally expressing PML/RAR (U937-PR), (Grignani et al. 1993) (Alcalay et al. 2003), and comp...
ORGANISM(S): Homo sapiens 
2004-12-31 | E-MEXP-149 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human U937 cells expressing AML1/ETO compared to vector transfected U937 cells to identify genes regulated by AML1/ETO
Approximately 20% of Acute Myelogenous Leukemia (AML) cases carry the t(8;21) translocation, which involves the AML1 and ETO genes, and express the resulting AML1/ETO fusion protein that functions as a transcriptional repressor by recruiting NCoR/SMRT/HDAC complexes to DNA. We used microarrays to id...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-10520 | biostudies-arrayexpress
TranscriptomicsGenes regulated after knock-down of Pirin in U937 cells
Pirin (PIR) is a putative transcriptional regulator whose expression is silenced in cells bearing the AML1/ETO and PML/RAR leukemogenic fusion proteins and is significantly repressed in a large proportion of acute myeloid leukemias. PIR expression increases during in vitro myeloid differentiation of...
ORGANISM(S): Homo sapiens 
2009-12-10 | E-GEOD-16798 | biostudies-arrayexpress
TranscriptomicsGenes regulated in EML1 cells expressing the TEL-AML1 oncogene after 5 and 7 days of treatment with IL7 and FLT3 ligand.
The t(12;21) translocation is the most common genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) and gives rise to the TEL-AML1 fusion gene, which functions as a transcription factor. TEL-AML1 expression in EML1 cells results in an impairment of differentiation along the B-lymphoi...
ORGANISM(S): Mus musculus 
2015-05-13 | E-GEOD-64919 | biostudies-arrayexpress
TranscriptomicsGene expression profile and DNA binding pattern of AML1/ETO in U937 cells
This SuperSeries is composed of the following subset Series: GSE10520: Genes regulated by AML1/ETO in U937 cells GSE10537: Gene expression profiling of AML1/ETO regulated genes and binding pattern on human promoters in U937 cells GSE10578: AML1/ETO, AML1, and HEB binding patterns on chromosme 19 GSE...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10537 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of dissected neuroepithelium (Neur.) and from all other non-neuroepithelial tissues (N. Neur for Non Neuronal tissues) from six wild type (WT) and six Mdm4-null mouse embryos (KO)
Total RNA was isolated from the dissected neuroepithelium (Neur.) and from all other non-neuroepithelial tissues (N. Neur for Non Neuronal tissues) from six wild-type (WT) and six Mdm4-null embryos (KO). Equal quantities of total RNA from single samples were used to obtain four RNA pools (WT-Neur, W...
ORGANISM(S): Mus musculus 
2004-12-31 | E-MEXP-155 | biostudies-arrayexpress
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