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MetabolomicsIntegrated Analyses of the Gut Microbiota, Intestinal Permeability and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome
The etiology of alcohol dependence is not completely understood. Increasing evidence reveals that gut microbiota dysbiosis is associated with certain psychiatric disorders, including alcoholism, through the 'microbiota-gut-brain' axis. The aims were to evaluate the effect of alcohol abuse on the gut...
2021-07-30 | MTBLS2688 | MetaboLights
MetabolomicsFasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis

Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable. Harmful use of alcohol is one of the greatest risk factors for de...

2023-05-15 | MTBLS5071 | MetaboLights
TranscriptomicsGenes associated with alcohol abuse and nicotine addiction in the human nucleus accumbens
Background: The incidence of alcohol and tobacco co-abuse is as high as 80%. The molecular mechanism underlying this comorbidity is virtually unknown but interactions between these drugs have important implications for the development of, and recovery from drug dependence. Methods: We investigat...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-20568 | biostudies-arrayexpress
GenomicsAlcohol Dependence GWAS in European- and African Americans

This study includes SSADDA (Semi Structured Assessment for Drug Dependence and Alcoholism) assessed subjects (mostly unrelated, but including some affected sibling pairs) recruited in the course of several substance dependence genetics projects. The sample includes 1889 African-American (AA) subj...

phs000425.v1.p1 | EGA
GenomicsCIDR Alcohol Dependence
CIDR Alcohol Dependence
PRJNA75517 | ENA
TranscriptomicsmicroRNA Expression based, Effects of Chronic Intermittent Ethanol paradigm on mouse brain
We analyzed cerebral cortices (CTX) and midbrains (MB) from male C57BL/6J mice subjected to a CIE, 2BC paradigm, which induces heavy drinking and represents one of the best available animal models for alcohol dependence and relapse drinking. Samples from CTX and MB of 21 mice: 7 Naïve, 7 Air-2BC, an...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-48576 | biostudies-arrayexpress
GenomicAlcohol Dependence GWAS in European- and African Americans

This study includes SSADDA (Semi Structured Assessment for Drug Dependence and Alcoholism) assessed subjects (mostly unrelated, but including some affected sibling pairs) recruited in the course of several substance dependence genetics projects. The sample includes 1889 African-American (AA) subj...

phs000425 | dbGaP
TranscriptomicsEpigenome analysis of alcohol consumption in lymphocyte cell (LC) samples
Genome-wide DNA methylation profiling of individuals consuming alcohol and controls in LC samples. Individuals consuming alcohol were profiled at time of intake (T1) into treatment facility and four weeks into treatment (T2). Controls were profiled once. The Illumina Infinium 450k Human DNA Methylat...
ORGANISM(S): Homo sapiens 
2014-09-24 | E-GEOD-57853 | biostudies-arrayexpress
TranscriptomicsParental binge alcohol abuse alters F1 generation hypothalamic gene expression in the absence of direct fetal alcohol exposure
Adolescent binge alcohol exposure has been previously shown to have long-lasting effects on the expression of hypothalamic genes that regulate the stress response, even in the absence of subsequent adult alcohol exposure. Those data suggested that alcohol can induce permanent gene expression changes...
ORGANISM(S): Rattus norvegicus 
2014-03-19 | E-GEOD-53028 | biostudies-arrayexpress
TranscriptomicsPhenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster
Alcoholism is a complex disorder determined by interactions between genetic and environmental risk factors. Drosophila represents a powerful model system to dissect the genetic architecture of alcohol sensitivity, as large numbers of flies can readily be reared in defined genetic backgrounds and und...
ORGANISM(S): Drosophila melanogaster 
2008-03-13 | E-GEOD-7614 | biostudies-arrayexpress
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