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MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
TranscriptomicsmRNA expression profiles of TAE-684 treated or shALK transfected neuroblastoma cell lines
Human wild-type ALK (SK-N-AS, NGP, IMR-32), ALKR1275Q (CLB-GA, LAN-5, UKF-NB-3), ALKF1174L (SK-N-SH, Kelly, SMS-KCNR) and ALK amplified (NB-1) neuroblastoma cell lines were treated in triplicate with 0.3M-k_M NPV-TAE-684 (Novartis/SelleckChem) or DMSO (VWR) for 6 hours, followed by RNA isolation and...
ORGANISM(S): Homo Sapiens 
2015-05-04 | E-MTAB-3205 | biostudies-arrayexpress
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
UnknownA revision of Dolichogenidea (Hymenoptera, Braconidae, Microgastrinae) with the second mediotergite broadly rectangular from Area de Conservacion Guanacaste, Costa Rica.
Not available
S-EPMC6477850 | biostudies-literature
UnknownContrafreeloading in kea (Nestor notabilis) in comparison to Grey parrots (Psittacus erithacus).
Not available
S-EPMC9579195 | biostudies-literature
GenomicsTargeted disruption of DNMT1, 3A and 3B in human embryonic stem cells [DNMT3A/3B DKO]
DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Somatic patterns of DNA methylation are largely static, apart from focal dynamics at gene regulatory elements. To further advance our understanding of the role of DNA methylatio...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-63280 | biostudies-arrayexpress
GenomicsTargeted disruption of DNMT1, 3A and 3B in human embryonic stem cells [DNMT1]
DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Somatic patterns of DNA methylation are largely static, apart from focal dynamics at gene regulatory elements. To further advance our understanding of the role of DNA methylatio...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-63279 | biostudies-arrayexpress
GenomicsRRBS profiling of mouse ESCs (wild type and DNMT KOs)
DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Somatic patterns of DNA methylation are largely static, apart from focal dynamics at gene regulatory elements. To further advance our understanding of the role of DNA methylatio...
ORGANISM(S): Mus musculus 
2015-04-13 | E-GEOD-67811 | biostudies-arrayexpress
GenomicsIdentification of novel imprinted differentially methylated regions by global analysis of human parthenogenetic induced pluripotent stem cells
Parental imprinting is an epigenetic phenomenon by which genes are expressed in a monoallelic fashion, according to their parent-of-origin. DNA methylation is considered the hallmark mechanism regulating parental imprinting. To identify imprinted differentially methylated regions (DMRs), we compared...
ORGANISM(S): Homo sapiens 
2013-06-12 | E-GEOD-47088 | biostudies-arrayexpress
UnknownReduced-Intensity Transplantation for Lymphomas Using Haploidentical Related Donors Versus HLA-Matched Sibling Donors: A Center for International Blood and Marrow Transplant Research Analysis.
Not available
S-EPMC5012706 | biostudies-literature
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