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TranscriptomicsscRNA-seq of human trophoblast organoids EVT-differentiated in 21%, 8%, and 3% oxygen
Placental development occurs in a low oxygen environment, yet how oxygen tension instructs differentiation of progenitor cytotrophoblasts (CTB) along the extravillous versus villous pathways remains incompletely understood. In particular, the role of low oxygen in early extravillous trophoblast (EVT...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-16328 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human MCF cells treated with estrogen
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in b...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-11324 | biostudies-arrayexpress
TranscriptomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
2018-06-26 | E-MTAB-6781 | biostudies-arrayexpress
TranscriptomicsDiagnostic utility of high quality RNA in diverse clinical semen and sperm samples
We report quantitation of specific mRNAs in two RNA samples isolated from normozoospermic whole semen Examination of 2 different normozoospermic semen samples by RNA-seq Please note that raw data for 'GSM1273824: AY4' is incomplete.
ORGANISM(S): Homo sapiens 
2013-11-23 | E-GEOD-52665 | biostudies-arrayexpress
TranscriptomicsRandom monoallelic expression in the mouse: SNP array data
Random monoallelic expression is defined by the allele-specific expression of genes, and by the fact that for an individual cell this monoallelic expression is neither obligate nor necessarily coordinated with the allelic expression in other cells. In order to find novel examples of random monoallel...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-35678 | biostudies-arrayexpress
TranscriptomicsGBM-Space: Joint Transcriptome and Chromatin Accessibility Profiling of Glioblastoma (10x Genomics - Multiome)
Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single cell and spatial multi-omic a...
ORGANISM(S): Homo sapiens 
2026-09-12 | E-MTAB-17183 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human Acute Myeloid Leukemia samples
Not available
ORGANISM(S): Homo sapiens 
2011-01-21 | E-TABM-978 | biostudies-arrayexpress
TranscriptomicsGBM-Space: Spatial Transcriptomic Profiling of Glioblastoma (10x Genomics - Visium)
Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single cell and spatial multi-omic a...
ORGANISM(S): Homo sapiens 
2026-09-12 | E-MTAB-17164 | biostudies-arrayexpress
TranscriptomicsGenetic Manipulation of Putrescine Biosynthesis Reprograms the Cellular Transcriptome and the Metabolome
Background: With the increasing interest in metabolic engineering of plants using various genetic manipulation and gene editing technologies in order to enhance their growth, nutritional value and environmental adaptation, a major concern is the potential of broad and distant effects of manipulating...
ORGANISM(S): Populus maximowiczii x Populus nigra 
2016-03-24 | E-GEOD-79420 | biostudies-arrayexpress
GenomicsHuman RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors.
RNA polymerase (Pol) III transcribes many noncoding RNAs (for example, transfer RNAs) important for translational capacity and other functions. We localized Pol III, alternative TFIIIB complexes (BRF1 or BRF2) and TFIIIC in HeLa cells to determine the Pol III transcriptome, define gene classes and r...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-20309 | biostudies-arrayexpress
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