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TranscriptomicsChIP-chip by array of GFP-tagged dFOXO expressed in Drosophila melanogaster adult gut and fat body
ChIP-chip by array of GFP-tagged dFOXO expressed in Drosophila melanogaster adult gut and fat body
ORGANISM(S): Drosophila melanogaster 
2014-08-18 | E-MTAB-1021 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of adult Drosophila melanogaster gut and fat body in S1106>dfoxo females after 5 days of induction of transgene expression by RU486 feeding.
Transcription profiling by array of adult abdominal/thorasic fat body or midgut in S1106>dfoxo females after 5 days of induction of transgene expression by RU486 feeding.
ORGANISM(S): Drosophila melanogaster 
2014-08-18 | E-MTAB-1020 | biostudies-arrayexpress
TranscriptomicsInduction of AopACT in adult Drosophila abdominal fat body
Transcript profiling of adult abdominal fat body in S1106>AopACT females after 5 days of induction of transgene expression by RU486 feeding.
ORGANISM(S): Drosophila melanogaster 
2014-08-18 | E-MTAB-927 | biostudies-arrayexpress
TranscriptomicsAopACT binding in adult gut and fat body upon its induction in Drosophila melanogaster
ChIP-chip on FLAG-tagged AopACT expressed in adult gut and fat body.
ORGANISM(S): Drosophila melanogaster 
2014-08-18 | E-MTAB-1306 | biostudies-arrayexpress
TranscriptomicsdFOXO targets in Drosophila melanogaster
dFOXO targets in adult Drosophila melanogaster females, and the effect of insulin signalling and stress on binding. The experimets determined the binding locations of dFOXO in the whole adult female fly using ChIP-chip. The protocol was validated using mock conditions: pre-immune serum or IP on chro...
ORGANISM(S): Drosophila melanogaster 
2011-06-18 | E-TABM-751 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of dInR and dfoxo epistasis in Drosophila melanogaster
Transcriptional analysis of dInR and dfoxo epistasis in Drosophila melanogaster. The experiment was performed to examine which parts of the transcriptional response to a reduction in insulin signalling in an adult female fly depend on the presence of the dfoxo transcription factor. Whole fly transcr...
ORGANISM(S): Drosophila melanogaster 
2011-06-18 | E-TABM-757 | biostudies-arrayexpress
TranscriptomicsNutritional programming of lifespan: Excessive sugar consumption in early adulthood curtails Drosophila survival by inhibiting dFOXO
Fruit flies were maintained either 40% sugar or 5% sugar diets for one week, then on 5% sugar for one further week. Whole flies were sampled at the end of weeks 1 and week 2. Persistent effects of past high sugar diets are identified.
ORGANISM(S): Drosophila melanogaster 
2017-01-11 | E-MTAB-4766 | biostudies-arrayexpress
MetabolomicsTranscriptional memory of dFOXO activation in youth curtails later-life mortality
Identifying processes occurring in early life affect subsequent life and health span is an urgent aim to improve human health. In this study, we identified a novel mechanism of dFOXO in longevity determination in Drosophila. We found that early adulthood induction of dFOXO is sufficient to reduce mo...
2022-09-28 | MTBLS3251 | MetaboLights
TranscriptomicsIntestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
We identified that Drosophila FoxA transcription Fork Head (FKH) function is necessary for reduced insulin signalling and rapamycin induced longevity. Furthermore, we determined that FKH function in the gut tissue alone is sufficient to extend lifespan. We carried out RNA-sequencing in gut tissue o...
ORGANISM(S): Drosophila melanogaster 
2017-09-23 | E-MTAB-6056 | biostudies-arrayexpress
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