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ProteomicsSDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species
Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous termin...
ORGANISM(S): Homo sapiens (Human) 
2022-05-10 | PXD033059 | Pride
Cancer Isodtb Sdr enzymes Alkynylcarbinol 
UnknownA plug and play approach to structural variations of bio-inspired anticancer lipidic phenyl dialkynylcarbinols.
Not available
S-EPMC12519321 | biostudies-literature
UnknownSDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.
Not available
S-EPMC9090334 | biostudies-literature
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