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TranscriptomicsEphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts
With the aim of identifying new pathways and genes regulated by PTH(1-34) and PTH-related protein 1-141 [PTHrP(1-141)] in osteoblasts, this study was carried out using a mouse marrow stromal cell line, Kusa 4b10, that acquires features of the osteoblastic phenotype in long-term culture conditions. A...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-45895 | biostudies-arrayexpress
TranscriptomicsRole of Aldoketoreductases and Other Doxorubicin Pharmacokinetic Genes in Doxorubicin Resistance, DNA binding, and Subcellular Localization
Objective: To assess the role of aldoketoreductases and other doxorubicin pharmacokinetic or pharmacogenomic genes in doxorubicin cytotoxicity, resistance, DNA binding activity, and subcellular localization, Methods: We conducted a whole genome microarray study to identify differences in betwee...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-27254 | biostudies-arrayexpress
TranscriptomicsDrosophila Staged follicles
Gene expression analysis of yw follicles at S9/10a, S10B, S12, and S14; Gene expression analysis of pxt mutant follicles (f01000 and EY03052) at S10B, S12, S14 Drosophila ovarian follicles complete development using a spatially and temporally controlled maturation process in which they resume meiosi...
ORGANISM(S): Drosophila melanogaster 
2011-06-09 | E-GEOD-29815 | biostudies-arrayexpress
TranscriptomicsCombinatorial binding of transcription factors in the pluripotency control regions of the genome
The pluripotency control regions (PluCRs) are defined as genomic regions that are bound by Oct4, Sox2, and Nanog in vivo. We utilized a high-throughput binding assay to record more than 270,000 different DNA/protein binding measurements along incrementally tiled windows of DNA within these PluCRs. T...
ORGANISM(S): Homo sapiens 
2011-03-03 | E-GEOD-27535 | biostudies-arrayexpress
GenomicsXXX
GenomeEUtwin control samples
EGAD00000000043 | EGA
GenomicsGeographical structure and differential natural selection among North European populations
European populations and epidemiological cohorts are of special significance in the current era of genomic research aiming to characterize the background of common human diseases. The genome sequence, detailed information of genetic variations between individuals, high-throughput molecular technolog...
EGAS00000000033 | EGA
GenomicsGenomeEUtwin Data Access Committee
Access to data generated by the GenomeEUtwin is available by emailing application to the data access committee and will be granted to qualified investigators for appropriate use.
EGAC00000000007 | EGA
TranscriptomicsAvian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing.
RNAseq analysis of caecal tissue from 14 C. jejuni-susceptible and 14 C. jejuni-resistant birds from a single population of infected chickens was conducted in order to identify gene expression associated with resistance to colonization. Significantly higher expression of genes involved in the innate...
ORGANISM(S): Gallus gallus 
2013-02-15 | E-GEOD-44341 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human cancer cell lines upon ZMPSTE24 silencing
Defining the aging-cancer relationship is a challenging task. Mice deficient in Zmpste24, a metalloproteinase mutated in human progeria and involved in nuclear prelamin A maturation, recapitulate many features of aging. However, their short lifespan and cell-intrinsic and -extrinsic alterations rest...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-41799 | biostudies-arrayexpress
TranscriptomicsExpression Profiles of Monozygotic Twin
The expression level for 15 887 transcripts in lymphoblastoid cell lines from 19 monozygotic twin pairs (10 male, 9 female) were analysed for the effects of genotype and sex. On an average, the effect of twin pairs explained 31% of the variance in normalized gene expression levels, consistent with p...
ORGANISM(S): Homo sapiens 
2008-03-30 | E-GEOD-7624 | biostudies-arrayexpress
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