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TranscriptomicsAllelic imbalance sequencing reveals that single-nucleotide polymorphisms frequently alter microRNA-directed repression
Genetic changes that help explain the differences between two individuals might create or disrupt sites complementary to microRNAs (miRNAs), but the extent to which such polymorphic sites influence miRNA-mediated repression is unknown. Here, we describe a method to measure mRNA allelic imbalances as...
ORGANISM(S): Mus musculus 
2009-04-26 | E-GEOD-15675 | biostudies-arrayexpress
TranscriptomicsGenomic landscape affected by allelic imbalance in the cancerization filed of normal appearing airway
Normal appearing airway samples from non-small cell lung (NSCLC) cancer patients were profiled using illumina sequencing arrays. Allelic imbalance was detected in normal-appearing large and small airway samples and affected known lung cancer driver genes. Multiple airway samples from 45 patients wer...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-80519 | biostudies-arrayexpress
TranscriptomicsAllelic imbalance is a prevalent and tissue-specific feature of the mouse transcriptome
We perform a systematic classification of allelic imbalance in mouse hybrids derived from reciprocal crosses of divergent strains. We observe that deviation from balanced biallelic expression is common, occurring in ~20% of the mouse transcriptome. Allelic imbalance attributed to genotype is by far ...
ORGANISM(S): Mus musculus 
2015-05-28 | E-GEOD-58524 | biostudies-arrayexpress
GenomicsDynamic allelic imbalance in early mouse embryo
Dynamic allelic imbalance in early mouse embryo
PRJNA524173 | ENA
TranscriptomicsAn integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer: allelic status
dChip analysis of 9 breast cancer cell lines. Data obtained from caBIG Part of a multi-dimensional analysis of gene copy number, allelic status, DNA methylation and gene expression data
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21347 | biostudies-arrayexpress
GenomicsContribution of allelic imbalance to colorectal cancer
Point mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (AI) landscape in 1699 colorectal cancers, 256 of which have been whole genome sequenced ...
EGAS00001002966 | EGA
TranscriptomicsRNA-Seq of oral squamous cell carcinomas and matched normal tissues
RNA-Seq was applied to oral squamous cell carcinomas and matched normal oral tissue to measure gene expression patterns and identify examples of allelic imbalance. Oral squamous cell carcinomas (OSCC) and matched normal tissue from 3 patients.
ORGANISM(S): Homo sapiens 
2010-02-25 | E-GEOD-20116 | biostudies-arrayexpress
TranscriptomicsTelomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents
DNA repair competency is one determinant of sensitivity to certain chemotherapy drugs, such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome damage during growth and also can repair platinum-induced DNA damage. We sought genomic signatures indicative of defectiv...
ORGANISM(S): Homo sapiens 
2012-03-22 | E-GEOD-28330 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing reveals allelic expression imbalance in the diploid pathogen Candida albicans
The diploid fungal pathogen Candida albicans is a highly heterozygous organism, with numerous non-synonymous substitutions often seen within two alleles. RNA-sequencing of the wild-type strain SC5314 has revealed 233 genes with significant levels of allelic expression imbalance. Overall percentage p...
ORGANISM(S): Candida albicans 
2014-06-30 | E-GEOD-35233 | biostudies-arrayexpress
GenomicsDeveloping Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
Developing Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
PRJNA1149106 | ENA
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