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TranscriptomicsTranscription profiling of human airway epithelial cells before and after segmental allergen challenge to identify effects of allergen challenge on airway epithelial cell gene expression
Allergen exposure induces the airway epithelium to produce chemoattractants, proallergic interleukins, matrix-modifying proteins, and proteins that influence the growth and activation state of airway structural cells. These proteins, in turn, contribute to the influx of inflammatory cells and change...
ORGANISM(S): Homo sapiens 
2007-11-21 | E-GEOD-3004 | biostudies-arrayexpress
MetabolomicsUmbilical cord blood metabolome differs in relation to delivery mode, birth order and sex, maternal diet and possibly future allergy development in rural children
Allergy is one of the most common diseases among young children yet all factors that affect development of allergy remain unclear. In a small cohort of 65 children living in the same rural area of south-west Sweden, we have previously found that maternal factors, including prenatal diet, affect chil...
2020-12-18 | MTBLS2017 | MetaboLights
MetabolomicsExploring the Fecal Metabolome in Infants With Cow's Milk Allergy: The Distinct Impacts of Cow's Milk Protein Tolerance Acquisition and of Synbiotic Supplementation.

SCOPE: Cow's milk allergy (CMA) is one of the most prevalent food allergies in early childhood, often treated via elimination diets including standard amino acid-based formula or amino acid-based formula supplemented with synbiotics (AAF or AAF-S). This work aimed to assess ...

2024-09-02 | MTBLS8954 | MetaboLights
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
TranscriptomicsTranscription profiling by array of mouse BALBc strain mesenteric lymph nodes after response to common allergens.
In this study, MLN transcriptome profiling of female BALB/c mice was conducted in order to explore the molecular mechanism(s) of antigen sensitization using three of the most common food allergens; BLG, OVA and PNA. Analysis of cDNA microarray data revealed a complex network of genes that is modulat...
ORGANISM(S): Mus musculus 
2011-05-11 | E-MEXP-2676 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human memory T cells stimulated with Phl p-extract in healthy and allergic individuals
Differential transcriptional response of memory T cells stimulated with Phl p-extract in healthy and allergic individuals.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-243 | biostudies-arrayexpress
ProteomicsProtein profiling of human serum against a panel of allergens.
Current diagnostics for allergies, such as skin prick and radioallergosorbent tests, do not allow for inexpensive, high-throughput screening of patients. Additionally, extracts used in these methods are made from washed pollen that lacks pollen surface materials that may contain allergens. We soug...
ORGANISM(S): Homo sapiens 
2010-09-08 | E-MTAB-177 | biostudies-arrayexpress
TranscriptomicsPooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma
We performed a pooled GWAS and individual genotyping in 269 children with allergic respiratory diseases comparing allergic children with and without asthma. We used a modular approach to identify the most significant loci associated with asthma by combining silhouette statistics and physical distanc...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-24481 | biostudies-arrayexpress
TranscriptomicsComparison of two sets of microarray experiments to define allergic asthma expression pattern
Allergic asthma is a complex trait. Several approaches have been used to identify biomarkers involved in this disease. This study aimed at demonstrating the relevance and validity of microarrays in the definition of allergic asthma expression pattern. The authors compared the transcript expressions ...
ORGANISM(S): Homo sapiens 
2012-10-18 | E-GEOD-41649 | biostudies-arrayexpress
MetabolomicsDelayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; ...
2024-10-24 | MTBLS7919 | MetaboLights
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