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MetabolomicsGinsenoside Rd2 improves allergic asthma by inhibiting PTGS2 enzyme activity
This study aims to elucidate the molecular mechanisms underlying the therapeutic effects of mountain-grown ginseng in allergic asthma and to systematically identify and characterize bioactive monomeric compounds responsible for these effects. We found that total saponins from mountain-grown ginseng ...
2026-04-13 | MTBLS14268 | MetaboLights
MetabolomicsDelayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur in parallel; ...
2024-10-24 | MTBLS7919 | MetaboLights
TranscriptomicsComparison of two sets of microarray experiments to define allergic asthma expression pattern
Allergic asthma is a complex trait. Several approaches have been used to identify biomarkers involved in this disease. This study aimed at demonstrating the relevance and validity of microarrays in the definition of allergic asthma expression pattern. The authors compared the transcript expressions ...
ORGANISM(S): Homo sapiens 
2012-10-18 | E-GEOD-41649 | biostudies-arrayexpress
TranscriptomicsPooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma
We performed a pooled GWAS and individual genotyping in 269 children with allergic respiratory diseases comparing allergic children with and without asthma. We used a modular approach to identify the most significant loci associated with asthma by combining silhouette statistics and physical distanc...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-24481 | biostudies-arrayexpress
MetabolomicsCD5L inhibits allergic airway inflammation by lysophosphatidylcholine-induced ILC2 apoptosis

Group 2 innate lymphoid cells (ILC2s) play key roles in allergic asthma development. We have previously revealed the inhibitory effect of CD5 antigen-like protein (CD5L) on allergic airway inflammation. Here, we analyzed the effect of CD5L on ILC2s.

2025-09-04 | MTBLS12937 | MetaboLights
MetabolomicsLysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have indicated a potential relationship between lysosomes and eosinophils, the precise role of lysosomes in eosinophil acti...

2025-09-15 | MTBLS13001 | MetaboLights
TranscriptomicsExpression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma
This SuperSeries is composed of the following subset Series: GSE15345: Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma 1 GSE15414: Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma 2...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-15429 | biostudies-arrayexpress
TranscriptomicsGene expression pattern of alveolar macrophages of allergic asthmatics in comparison with control subjects
The implication of alveolar macrophages (AM) in asthma, a Th2 disease, has not been well characterized. Thus, the goal of this study is to better characterize AM phenotype of allergic asthmatic compared with normal subjects using genomic expression analyses. Microarray analyses were performed with A...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22528 | biostudies-arrayexpress
ProteomicsTargeting mitochondrial reactive oxygen species alleviates allergic airway disease in a mouse model of obese allergic asthma
Obesity is associated with severe, difficult to control asthma, and increased airway oxidative stress. Mitochondrial reactive oxygen species (mROS) are an important source of oxidative stress leading us to hypothesize that targeting mROS in obese allergic asthma might be an effective treatment strat...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2023-06-02 | PXD029715 | Pride
Obesity Mitochondrial reactive oxygen species (mros) Allergic asthma Airway oxidome Unfolded protein response (upr). Mitoquinone Tissue eosinophilia 
TranscriptomicsNext-Generation Transcriptome Sequencing (RNA-Seq) of Human Endobronchial Biopsies: Asthma vs Controls
Rationale: The cellular and molecular pathways in asthma are highly complex. Increased understanding can be obtained by unbiased transcriptomic analysis (RNA-Seq). Hypothesis and Aims: We hypothesized that the transcriptomic profile of whole human endobronchial biopsies differs between patients with...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-38994 | biostudies-arrayexpress
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