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TranscriptomicsGene expression profiling in WT and Alox15-/- HSCs
To understand the underlying mechanism by which Alox15 gene is required by HSCs, we performed a comparative DNA microarray analysis using total RNA isolated from wild type Lin-Sca-1+c-Kit+, Alox5-/- Lin-Sca-1+c-Kit+. The result was validated by quantitative real-time PCR analysis of wild type Lin-Sc...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29348 | biostudies-arrayexpress
ProteomicsLC-MS/MS analysis of MAVS-interacting proteins in H1N1-infected A549 cells with ALOX15 overexpression
To identify the key molecules involved in ALOX15-mediated K63-linked ubiquitination of MAVS, we performed LC-MS/MS-based proteomics analysis of MAVS-interacting proteins in H1N1-infected A549 cells transfected with Flag-ALOX15 or plasmid vector. This analysis identified USP19, a deubiquitinase, as a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD078482 | Pride
Usp19 Virus Alox15 Mavs Ubiquitination Deubiquitinase Lc-ms/ms 
TranscriptomicsRNA-Seq of wounds comparing gene expression in wild type and Alox15 deficient mice during day 0, day 4 and day 7 post-wounding.
Alox15 is a gene which encodes 12/15-LOX, an enzyme that generates bioactive lipid mediators. This experiment is designed to look at the impact of genetic deletion of Alox15 in punch wounds in skin, in order to determine how the protein may be involved in regulating wound healing. Punch wounds w...
ORGANISM(S): Mus musculus 
2023-06-21 | E-MTAB-12845 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in WT and Alox15-/- HSCs
To understand the underlying mechanism by which Alox15 gene is required by HSCs, we performed a comparative DNA microarray analysis using total RNA isolated from wild type Lin-Sca-1+c-Kit+, Alox5-/- Lin-Sca-1+c-Kit+. The result was validated by quantitative real-time PCR analysis of wild type Lin-Sc...
ORGANISM(S): Mus musculus 
2011-05-17 | GSE29348 | GEO
UnknownConformational Heterogeneity and Cooperative Effects of Mammalian ALOX15.
Not available
S-EPMC8004969 | biostudies-literature
GenomicsAlox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity.
Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity.
PRJNA1502982 | ENA
GenomicsAlox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity.
Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity.
PRJNA1510659 | ENA
UnknownLuteolin Attenuates Asthma Via Inhibiting ALOX15 Mediated Bronchial Epithelial Cell Ferroptosis.
Not available
S-EPMC12876095 | biostudies-literature
UnknownThe Unexpected Protective Role of Thrombosis in Lung Injury via Endothelial Alox15.
Not available
S-EPMC12724588 | biostudies-literature
UnknownALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Not available
S-EPMC5509529 | biostudies-literature
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