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ProteomicsCardiomyocyte external mechanical unloading activates modifications of alpha-actinin differently from sarcomere-originated unloading
Loss of myocardial mass in a neonatal rat cardiomyocyte culture is studied to determine whether there is a distinguishable cellular response based on the origin of mechano-signals. The approach herein compares the sarcomeric assembly and disassembly processes in heart cells by imposing mechano-signa...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-05 | MSV000091010 | MassIVE
ProteomicsLoss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation
The fast skeletal muscle protein α-actinin-3 is absent in 1.5 billion people worldwide due to homozygosity for a nonsense polymorphism in the ACTN3 gene (R577X). The prevalence of the 577X allele increased as modern humans moved to colder climates, suggesting a link between α-actinin-3 deficiency an...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-16 | PXD022997 | Pride
Α-actinin Evolution Muscle 
ProteomicsReversible SAHH inhibitor protects against glomerulonephritis in lupus-prone NZB/NZW F1 mice by modulating α-actinin-4 associated skeleton organization of podocytes
Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE). Podocytes can be injured in many forms of glomerular disease, characteristic changes are actin cytoskeleton reorganization of involved foot process. ACTN4, encodes α-actinin-4, an actin-bi...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010059 | Pride
Α-actinin-4 Integrin-linked kinase Podocyte injury Glomerulonephritis Sahh inhibitor Skeleton organization 
UnknownCharacterisation of Schizosaccharomyces pombe α-actinin.
Not available
S-EPMC4824898 | biostudies-literature
Unknownα-Actinin Anchors PSD-95 at Postsynaptic Sites.
Not available
S-EPMC5963734 | biostudies-literature
UnknownStructural and functional characterization of a plant alpha-actinin.
Not available
S-EPMC8329775 | biostudies-literature
UnknownHAMLET binding to α-actinin facilitates tumor cell detachment.
Not available
S-EPMC3050841 | biostudies-literature
UnknownStructural characterization of the interactions between palladin and α-actinin.
Not available
S-EPMC3226707 | biostudies-literature
UnknownCalcium affinity of human α-actinin 1.
Not available
S-EPMC4435478 | biostudies-literature
Unknownα-Actinin-2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α-actinin-3 revealing functional differences between sarcomeric isoforms.
Not available
S-EPMC3336783 | biostudies-literature
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