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TranscriptomicsTranscription profiling of mouse transgenics (3 mo) inducibly expresssing human alpha1-antitrypsin in the liver
In the classical form of α1antitrypsin deficiency a mutant protein accumulates in a polymerized form in the ER of liver cells causing liver damage and carcinogenesis by a gain-of-toxic function mechanism. Recent studies have indicated that the accumulation of mutant α1antitrypsin Z in the ER spec...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8599 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse (6 wk) inducibly expresssing human alpha1-antitrypsin in the liver
In the classical form of α1antitrypsin deficiency a mutant protein accumulates in a polymerized form in the ER of liver cells causing liver damage and carcinogenesis by a gain-of-toxic function mechanism. Recent studies have indicated that the accumulation of mutant α1antitrypsin Z in the ER spec...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8600 | biostudies-arrayexpress
GenomicsAlpha1-Antitrypsin Deficiency Registry (AADR-BioLINCC)
Alpha1-Antitrypsin Deficiency Registry (AADR-BioLINCC)
PRJNA1296685 | ENA
GenomicsAlpha1-Antitrypsin Deficiency Registry (AADR-BioLINCC)
Alpha1-Antitrypsin Deficiency Registry (AADR-BioLINCC)
PRJNA1296684 | ENA
UnknownCase-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD.
Not available
S-EPMC5655868 | biostudies-literature
UnknownSARS-CoV-2 infection in alpha1-antitrypsin deficiency.
Not available
S-EPMC8116136 | biostudies-literature
GenomicsMice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
PRJNA884623 | ENA
TranscriptomicsMice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
Characterize how Balb/c mice responses to aerosolized LPS (lipopolysaccharide) alone or with intraperitoneal (i.p.) delivery of alpha1-antitrypsin (AAT)
ORGANISM(S): Mus musculus 
2022-09-30 | GSE214249 | GEO
ProteomicsCalreticulin enhances the secretory trafficking of a polymerogenic alpha1-antitrypsin
α-1-antitrypsin (AAT) regulates protease activity in the lungs and liver. The presence of one or more copies of a mutant Z allele (AAT (E342K), called ATZ), results in low serum levels of ATZ along with intracellular inclusions of polymeric forms, causing lung emphysema and liver cirrhosis. Our expe...
ORGANISM(S): Homo sapiens (Human) 
2020-09-24 | PXD020562 | Pride
Calreticulin Alpha1-antitrypsin Copii Secretory trafficking Calnexin 
UnknownImproving the Laboratory Diagnosis of M-like Variants Related to Alpha1-Antitrypsin Deficiency.
Not available
S-EPMC9456480 | biostudies-literature
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