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TranscriptomicsStudy the effect of calreticulin knockdown on genome-wide transcript expression in HepG2 cells
The objective was to evaluate the status of the global hepatic transcriptome in the presence of inhibited calreticulin levels. Results identify a total of 324 genes were altered of which 245 genes were downregulated and 79 genes were upregulated. This suggests that such altered genes might be associ...
ORGANISM(S): Homo sapiens 
2015-07-23 | E-GEOD-57261 | biostudies-arrayexpress
TranscriptomicsHuman MCF7 cells: Mock control vs. siRNA transfected against calreticulin
Transcriptional profiling of human MCF7 cells comparing mock control MCF7cells with MCF7cells transfected by siRNA against calreticulin. The latter was shown to be of having significantly decreased expression of calreticulin followed by significant decrease in migrative and invasive potentials of th...
ORGANISM(S): Homo sapiens 
2013-02-26 | E-GEOD-44371 | biostudies-arrayexpress
ProteomicsCalreticulin mutated hematopoietic cells are vulnerable to ATR-CHK1 pathway inhibition
Disease frameshift mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF). To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we aimed to search for small molecule drugs th...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD026803 | Pride
Mouse Mpn Calreticulin mutant Myeloproliferative neoplasms Atr-chk1 pathway 
GenomicsRNA-seq experiment of Calreticulin-mutated patients
RNA-seq experiment of Calreticulin-mutated patients
PRJNA655151 | ENA
ProteomicsCalreticulin enhances the secretory trafficking of a polymerogenic alpha1-antitrypsin
α-1-antitrypsin (AAT) regulates protease activity in the lungs and liver. The presence of one or more copies of a mutant Z allele (AAT (E342K), called ATZ), results in low serum levels of ATZ along with intracellular inclusions of polymeric forms, causing lung emphysema and liver cirrhosis. Our expe...
ORGANISM(S): Homo sapiens (Human) 
2020-09-24 | PXD020562 | Pride
Calreticulin Alpha1-antitrypsin Copii Secretory trafficking Calnexin 
TranscriptomicsRNA seq of natural killer (NK) cells of MPN patients with mutations in calreticulin (CALR) and healthy controls
To assess the transcriptional differences between natural killer (NK) cells from patients with myeloproliferative neoplasms (MPN) carrying a mutation in calreticulin (CALR) and healthy donors (HD), bulk RNA sequencing was performed. Peripheral blood mononuclear cells (PBMC) were isolated from the bl...
ORGANISM(S): Homo sapiens 
2026-09-30 | E-MTAB-16774 | biostudies-arrayexpress
GenomicsRNA-seq analysis of Calreticulin(Calr) knockout LLC cells identified ER stress response
RNA-seq analysis of Calreticulin(Calr) knockout LLC cells identified ER stress response
PRJNA1201200 | ENA
TranscriptomicsHuman MCF7 cells: Mock control vs. siRNA transfected against calreticulin
Transcriptional profiling of human MCF7 cells comparing mock control MCF7cells with MCF7cells transfected by siRNA against calreticulin. The latter was shown to be of having significantly decreased expression of calreticulin followed by significant decrease in migrative and invasive potentials of th...
ORGANISM(S): Homo sapiens 
2013-02-26 | GSE44371 | GEO
ProteomicsMHC class I-mediated antigen presentation is independent of calreticulin
TMT-MS analysis of the proteome in whole cell lysates from primary murine neutrophil granulocytes and CD8+ T cells obtained from mice carrying a calreticulin knock out or oncogenic mutation (CALRdel52)
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD062085 | Pride
Calreticulin Knock out Cd8+ t cells Tandem mass tag mass spectrometry Mutated Mouse Tmt-ms Myeloproliferative neoplasm Neutrophil granulocytes Calrdel52 
TranscriptomicsRNA-seq experiment of Calreticulin-mutated patients
We report the feature count (from HTSeq) of 6 calreticulin-mutated patients and 3 healty control.
ORGANISM(S): Homo sapiens 
2021-08-31 | GSE155663 | GEO
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