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GenomicsGene expression profile (GEP) of K562 cells expressing wtCALR, CALRins5 and CALRdel52
Gene expression profile (GEP) of K562 cells expressing wtCALR, CALRins5 and CALRdel52
PRJNA471305 | ENA
GenomicsMus musculus strain:C57Bl/6
Expression data of Lineage- Sca1+cKit+ (LSK) cells from wild-type, Calr+/-, CALRdel52 Calr+/+, or CALRdel52 Calr+/- mice.
PRJDB8643 | ENA
TranscriptomicsGene expression profile (GEP) of K562 cells expressing wtCALR, CALRins5 and CALRdel52
In this work, we compared gene expression profile (GEP) of K562 cells transduced with the retroviral vector LCALRins5IDN or LCALRdel52IDN with K562 cells transduced with LwtCALRIDN In order to unravel MPL-independent mechanisms underlying the effect of CALR mutations on MPN pathogenesis, we analysed...
ORGANISM(S): Homo sapiens 
2019-08-04 | GSE114414 | GEO
ProteomicsMHC class I-mediated antigen presentation is independent of calreticulin
TMT-MS analysis of the proteome in whole cell lysates from primary murine neutrophil granulocytes and CD8+ T cells obtained from mice carrying a calreticulin knock out or oncogenic mutation (CALRdel52)
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD062085 | Pride
Calreticulin Knock out Cd8+ t cells Tandem mass tag mass spectrometry Mutated Mouse Tmt-ms Myeloproliferative neoplasm Neutrophil granulocytes Calrdel52 
TranscriptomicsRNA-Seq of murine megakaryocyte progenitors (MkPs) from Cdk6 knockout and Cdk6 wild-type CALR-mutant mice
This experiment was performed to elucidate the effects of CDK6 on CALR-mutant Myeloproliferative Neoplasms. VavCre CALRdel52 knockin mice were crossed with full-body Cdk6-/- mice to obtain Cdk6-/- CALRdel52 mice. Bone marrow from mice of the four genotypes Cdk6+/+ CALR+/+ (wild-type), Cdk6+/+ CALRde...
ORGANISM(S): Mus musculus 
2026-08-03 | E-MTAB-15404 | biostudies-arrayexpress
TranscriptomicsOncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment - scRNAseq
We established a model for myeloproliferative disease in mice, that is based on primary bone marrow expressing human Thrombopoietin receptor and human mutant Calrdel52. To learn more about cellular and transcriptional rearrangements in the bone marrow we performed single cell RNA sequencing comparin...
ORGANISM(S): Mus musculus 
2024-05-30 | GSE241364 | GEO
UnknownInduced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms.
Not available
S-EPMC8196125 | biostudies-literature
TranscriptomicsWhole-genome CRISPR screening identifies N-glycosylation as an essential pathway and a potential novel therapeutic target in CALR-mutant MPN (RNA-Seq).
RNA-sequencing of megakaryocyte-erythroid progenitors of CALRdel52/+ MxCre mice treated with either vehicle or 2-deoxy-D-glucose for 21 days.
ORGANISM(S): Mus musculus 
2022-09-21 | GSE203457 | GEO
TranscriptomicsGene expression profile of hematopoietic stem cells from mutCALR transgenice mice
Transcriptome data of HSCs (Hematopoietic stem cells - LSKs) sorted from the bone marrow of vavCRE (wildtype) and CALRdel52 fl/fl; vavCre (mutCALR homozygous) mice
ORGANISM(S): Mus musculus 
2022-04-02 | GSE171563 | GEO
UnknownOncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment.
Not available
S-EPMC11405138 | biostudies-literature
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