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MetabolomicsTargeting CRBN to alter CD8 T cell metabolism
Not available
ORGANISM(S): Mus musculus 
ST000307 | MetabolomicsWorkbench
GenomicsGene profilling of splenic CD4+ T cells from naïve H2-O Wildtype and H2-O Knockout mice
Gene profilling of splenic CD4+ T cells from naïve H2-O Wildtype and H2-O Knockout mice
PRJNA1032139 | ENA
ProteomicsRegulation of Glycogen Synthase kinase 3beta by phosphorylation and O-beta-linked N-acetylglucosaminylation: implications on tau protein phosphorylation
Glycogen synthase kinase 3 (GSK3) plays a pivotal role in signaling pathways related to insulin metabolism and in the pathogenesis of Alzheimer s disease (AD) and other neurodegenerative disorders. More particularly, the GSK3beta isoform is involved in AD-associated tau pathology as one of the major...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-09 | MSV000094049 | MassIVE
ProteomicsStarvation-induced Hsc70 O-GlcNAcylation activates chaperone-mediated autophagy
O-linked β-N-acetylglucosamine (O-GlcNAc) functions as a nutrition rheostat to mediate cellular signaling pathways. It fluctuates in response to various nutritional factors, for instance, glucose. Previous investigations have shown that both glucose surplus and glucose deprivation upregulate O-GlcNA...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD070146 | Pride
Hsc70  o-glcnac  chaperone-mediated autophagy  ataxin-10  ogt 
ProteomicsSecretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation
EGF domains of human NOTCH3 were prepared from HEK293T cells.
ORGANISM(S): Homo Sapiens (human) 
2024-07-27 | PXD035703 | JPOST Repository
TranscriptomicsGene profilling of splenic CD4+ T cells from naïve H2-O Wildtype and H2-O Knockout mice
Loss of the MHC Class II accessory molecule H2-O has been shown to alter the peptide repertoir presented by MHC Class II molecules. Using scRNA-Seq we interrogated what outcomes altered antigen presentation was having on the naïve CD4 T cell milieu.
ORGANISM(S): Mus musculus 
2023-12-18 | GSE246253 | GEO
ProteomicsLoss of POGLUT2 and 3 eliminates O-glucose at predicted sites but does not alter other modifications on EGFs
Fibrillins play a critical role in tissue/organ development and cardiopulmonary function. Here we showed that O-glucosylation of the fibrillins’ epidermal growth factor-like repeats by protein O-glucosyltransferase 2 (POGLUT2) and POGLUT3 was indispensable for in vivo function of mouse fibrillins. L...
ORGANISM(S): Mus Musculus 
2024-06-10 | PXD043827 | panorama
ProteomicsGalectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatase Sulf-2
Human extracellular 6-O-endosulfatases Sulf-1 and Sulf-2 are the only enzymes that post-synthetically alter the 6-O sulfation of heparan sulfate proteoglycans (HSPG), which regulates interactions of HSPG with many proteins. Oncogenicity of Sulf-2 in different cancers has been documented and we have ...
ORGANISM(S): Homo Sapiens (human) 
2024-04-25 | PXD051711 | JPOST Repository
ProteomicsGalectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2
Human extracellular 6-O-endosulfatases Sulf-1 and Sulf-2 are the only enzymes that post-synthetically alter the 6-O sulfation of heparan sulfate proteoglycans (HSPG), which regulates interactions of HSPG with many proteins. Oncogenicity of Sulf-2 in different cancers has been documented and we have ...
ORGANISM(S): Homo Sapiens (human) 
2024-01-20 | PXD048713 | JPOST Repository
TranscriptomicsSustained increases in cardiomyocyte protein O-GlcNAc levels leads to cardiac hypertrophy and reduced mitochondrial function without systolic contractile impairment
Lifestyle and metabolic diseases influence the severity and pathogenesis of cardiovascular disease (CVD) through numerous mechanisms, including regulation via post-translational modifications (PTM). A specific PTM, the addition of O-linked β-N acetylglucosamine (O-GlcNAcylation), has been implicated...
ORGANISM(S): Mus musculus 
2023-08-19 | GSE211656 | GEO
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