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Proteomics5′ UTR length regulates the production of alternative N-terminal protein isoforms in health and disease
The 5′ untranslated region (5′ UTR) of an mRNA is classically viewed as a regulatory region that controls the amount of protein production, but not the resulting protein sequence. Here, we demonstrate that 5′ UTR length also plays a direct role in alternative N-terminal protein isoform production by...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD073007 | Pride
Cfd Translation initiation Alternative n-terminal isoform 
Genomics5′ UTR length shapes alternative N-terminal protein isoforms across cancers and in rare disease
5′ UTR length shapes alternative N-terminal protein isoforms across cancers and in rare disease
PRJNA1401761 | ENA
TranscriptomicsA retrotransposon-driven Dicer variant enhances endogenous RNAi in mouse oocytes
Mammals have one Dicer gene required for biogenesis of small RNAs in microRNA (miRNA) and RNA interference (RNAi) pathways. Yet, endogenous RNAi is highly active in oocytes but not in somatic cells. Here, we provide a mechanistical explanation for high RNAi activity in mouse oocytes. The main Dicer ...
ORGANISM(S): Mus musculus 
2013-11-07 | E-GEOD-41207 | biostudies-arrayexpress
ProteomicsAlternative splicing of Arabidopsis G6PD5 can recruits the NADPH-producing OPPP reactions to the endoplasmic reticulum
Glucose-6-phosphate dehydrogenase is the rate-limiting enzyme of the oxidative pentose-phosphate pathway (OPPP). The OPPP mainly provides NADPH and sugar-phosphate building blocks for anabolic pathways and is present in all eukaryotes. In plant cells, the irreversible part of the OPPP is found in se...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2022-07-11 | PXD035221 | JPOST Repository
Transcriptomics5′ UTR length shapes alternative N-terminal protein isoforms across cancers and in rare disease
The 5′ untranslated region (5′ UTR) of an mRNA is classically viewed as a regulatory region that controls the amount of protein production, but not the resulting protein sequence. Here, we demonstrate that 5′ UTR length also plays a direct role in alternative N-terminal protein isoform production by...
ORGANISM(S): Homo sapiens 
2026-01-15 | GSE316181 | GEO
Unknown5' UTR length regulates alternative N-terminal protein isoform production in health and disease.
Not available
S-EPMC12871742 | biostudies-literature
ProteomicsDNA damage-induced alternative splicing of p53
Samples were reduced in loading buffer and separated by SDS-PAGE for 3-4 min followed by in-gel digestion with trypsin. Digests were analyzed by LC-MS/MS using a Waters nanoACQUITY interfaced to a Thermo Fusion Lumos MS. The LC separation 90 min gradient of 5-30% MeCN in a trapping configurations w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-30 | MSV000086651 | MassIVE
TranscriptomicsTransformation of elongation factor 1Bdelta into heat shock response transcription factor by alternative splicing
Protein translation factors play crucial roles in a variety of stress responses. Here, we show that the eukaryotic elongation factor 1Bdelta (eEF1Bdelta) changes its structure and function from a translation factor into a heat shock response transcription factor by alternative splicing. While eEF1Bd...
ORGANISM(S): Homo sapiens 
2011-04-12 | E-GEOD-28506 | biostudies-arrayexpress
TranscriptomicsRNA-seq of different tissues from wild-type and C/EBPα ΔuORF mutant African turquoise killifish Nothobranchius furzeri
The transcription factor CCAAT/enhancer binding protein alpha (C/EBPα) regulates cell differentiation, proliferation, and function in various tissues, including the liver, adipose tissue, skin, lung, and hematopoietic system. Studies in rats, mice, humans, and chickens have shown that CEBPA mRNA und...
ORGANISM(S): Nothobranchius furzeri 
2026-05-26 | E-MTAB-15325 | biostudies-arrayexpress
ProteomicsImpact of alternative splicing on Arabidopsis proteome (Part I, AspN)
Alternative splicing (AS) is a key regulatory process in eukaryotes. Despite its importance, the impact of AS on proteome diversity in plants remains largely unexplored. Traditional tryptic digestion has limitations in detecting junction peptides because evolutionarily conserved nucleotide usage at ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-06-08 | PXD068586 | Pride
Tandem mass tags (tmt) Acinus Aspn Protease Proteome Transcriptomics Alternative splicing 
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