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MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
TranscriptomicsRegulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a g...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-16187 | biostudies-arrayexpress
TranscriptomicsBrd2 regulates gene expression and alternative splicing.
We analyzed a role of Brd2 protein in transcription and alternative splicing. 289 genes change alternative splicing after Brd2 knockdown and 1459 genes alter gene expression compared to cells treated with negative control siRNA. 6 samples (3 independent samples of cells treated with Brd2 siRNA, 3 sa...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-39937 | biostudies-arrayexpress
TranscriptomicsRegulation of alternative splicing by the core spliceosomal machinery
Abstract: Alternative splicing (AS) plays a major role in the generation of proteomic diversity and in gene regulation. However, the role of the basal splicing machinery in regulating AS remains poorly understood. Here we show that the core snRNP protein SmB/B’ self-regulates its expression by promo...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-26463 | biostudies-arrayexpress
TranscriptomicsAn Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [protein binding microarray]
Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity and the regulation of gene expression. However, the contribution of AS to the control of embryonic stem cell (ESC) pluripotency is not well understood. Here, we identify an evolutionarily conserved ESC-specifi...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-31007 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing reveals gene transcription activities and alternative splicing events in germinating barley embryos
Seed germination triggers a transition of growth and metabolic activities from quiescent to active statuses. Germinating seeds is a good system to study many biological and biochemical processes including hormone metabolic activities and cell wall biosynthesis. Next generation sequence technology is...
ORGANISM(S): Hordeum vulgare subsp. vulgare 
2016-02-18 | E-GEOD-66024 | biostudies-arrayexpress
TranscriptomicsAn Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming
This SuperSeries is composed of the following subset Series: GSE30995: An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [RNA-Seq] GSE31006: An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [ChIP-Seq] GSE31007: An A...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30992 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation.
Splicing factor SRSF10 is known to function as a sequence-specific splicing activator. Here, we used RNA-seq coupled with bioinformatics analysis to identify the extensive splicing network regulated by SRSF10 in chicken cells. We found that SRSF10 promoted both exon inclusion and exclusion. Function...
ORGANISM(S): Gallus gallus 
2014-01-22 | E-GEOD-53354 | biostudies-arrayexpress
TranscriptomicsPolypyrimidine tract-binding protein homologues from Arabidopsis are key regulators of alternative splicing with implications in fundamental developmental processes
Alternative splicing (AS) generates transcript variants by the definition of different exonic and intronic regions and causes a massive expansion of transcriptome diversity. Changes in AS patterns have been found to be linked to manifold biological processes, yet fundamental aspects such as the regu...
ORGANISM(S): Arabidopsis thaliana 
2012-10-22 | E-GEOD-41433 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of alternative splicing events in duplicated genes of Arabidopsis thaliana indicates considerable qualitative and quantitative divergence
Divergence of alternative splicing in duplicated genes is investigated Three replicates of RNA-seq for Arabidopsis first true leaf tissue
ORGANISM(S): Arabidopsis thaliana 
2014-09-30 | E-GEOD-57579 | biostudies-arrayexpress
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