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TranscriptomicsTranscription profiling of tungstate-induced beta cell mass increase in Rattus norvegicus subjects with induced diabetes
Background and Aims: It is well demonstrated that in the beta cell population of the pancreas there is a dynamic turnover, which results from the net balance of several processes; beta cell replication, apoptosis and neogenesis. These processes have been studied in partial pancreatectomy and glucago...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-2470 | biostudies-arrayexpress
TranscriptomicsKnockdown of Atoh8 in Neurog3-expressing mouse ductal cells mPAC results in altered expression of multiple cell cycle related genes
Atoh8 is a transcription factor of the basic-helix-loop-helix (bHLH) family that is expressed in multiple tissues during embryonic development but whose specific functions remain unknown. The gene encoding Atoh8 is induced by various lineage- determining bHLH transcription factors in cell culture, ...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-43536 | biostudies-arrayexpress
TranscriptomicsSecreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes ?-Cell Proliferation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2014-10-10 | E-GEOD-44047 | biostudies-arrayexpress
TranscriptomicsSecreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes β-Cell Proliferation [10 days]
Obesity is associated with an increase in β-cell mass in response to the rising demand for insulin. β-cell plasticity is essential to maintaining glucose homeostasis, however, the cellular and molecular mechanisms by which β-cell mass is regulated remain poorly understood. Recently, we described the...
ORGANISM(S): Rattus norvegicus 
2014-10-10 | E-GEOD-44045 | biostudies-arrayexpress
TranscriptomicsSecreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes ?-Cell Proliferation [30 days]
Obesity is associated with an increase in ?-cell mass in response to the rising demand for insulin. ?-cell plasticity is essential to maintaining glucose homeostasis, however, the cellular and molecular mechanisms by which ?-cell mass is regulated remain poorly understood. Recently, we described the...
ORGANISM(S): Rattus norvegicus 
2014-10-10 | E-GEOD-44046 | biostudies-arrayexpress
TranscriptomicsGene expression profile of sporadic and PSEN1 early-onset Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative dementia. Around 10% of cases present an age of onset before 65 years-old, which in turn can be divided in monogenic or familial AD (FAD) and sporadic early-onset AD (EOAD). Mutations in PSEN1, PSEN2 and APP genes have been linked with FA...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-39420 | biostudies-arrayexpress
TranscriptomicsThe role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice
AIMS/HYPOTHESIS: Manoeuvres aimed at increasing beta cell mass have been proposed as regenerative medicine strategies for diabetes treatment. Raf-1 kinase inhibitor protein 1 (RKIP1) is a common regulatory node of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways and...
ORGANISM(S): Mus musculus 
2012-11-19 | E-GEOD-31150 | biostudies-arrayexpress
TranscriptomicsRole of IGFBP-3 in the Regulation of β-Cell Mass during Obesity: Adipose Tissue/ β-Cell Cross Talk
In obesity an increase in β-cell mass occurs to cope with the rise in insulin demand. This β -cell plasticity is essential to avoid the onset of hyperglycemia, although the molecular mechanisms that regulate this process remain unclear. This study analyzed the role of adipose tissue in the control o...
ORGANISM(S): Rattus norvegicus 
2012-03-29 | E-GEOD-36935 | biostudies-arrayexpress
UnknownCirculating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease.
Not available
S-EPMC8544330 | biostudies-literature
TranscriptomicsDeletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to neurodegeneration and development of obesity
The activity of the endoribonuclease Dicer is crucial to produce the mature form of most microRNAs (miRNAs). Recent studies indicate that lack of miRNAs in different neuronal types results in a range of anatomical and behavioural phenotypes. In the present study we aimed to investigate the developme...
ORGANISM(S): Mus musculus 
2012-11-16 | E-GEOD-38672 | biostudies-arrayexpress
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