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MetabolomicsFunctional Remodeling of iNKT Cells by Sulfatide-Reactive Type II NKT Cells Reprograms Alveolar Macrophages to Alleviate Lung Ischemia-Reperfusion Injury

Lung ischemia-reperfusion injury (LIRI) is a serious complication in critical clinical situations. Despite its importance, the specific role of type II natural killer T (NKT) cells in LIRI remains unclear. In this study, we establish a LIRI mouse model and demonstrate that sulfatide-reactive type...

2025-12-19 | MTBLS13533 | MetaboLights
TranscriptomicsMouse GM-CSF-related alveolar macrophage genome-wide expression data
GM-CSF receptor-β deficient (Csf2rb–/– or KO) mice develop a lung disease identical to hereditary pulmonary alveolar proteinosis (hPAP) in humans with recessive CSF2RA or CSF2RB mutations that impair GM-CSF receptor function. We performed pulmonary macrophage transplantation (PMT) of bone marro...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-60528 | biostudies-arrayexpress
TranscriptomicsTranscription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.
Pulmonary alveolar proteinosis (PAP) results from a dysfunction of alveolar macrophages (AMs), chiefly due to disruptions in the signaling of granulocyte macrophage colony-stimulating factor (GM-CSF). We found that mice deficient for the B lymphoid transcription repressor BTB and CNC homology 2 (Bac...
ORGANISM(S): Mus musculus 
2014-01-15 | E-GEOD-54050 | biostudies-arrayexpress
TranscriptomicsCigarette smoking alters mRNA expression in human alveolar macrophages
Alveolar macrophages from never smokers and active smokers were isolated by bronchoalveolar lavage and gene expression was measured. Chronic cigarette smoke exposure, as occurs in smoker's lungs, leads to significant changes in gene expression. Of note, RNA was isolated immediately following bronch...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-34517 | biostudies-arrayexpress
TranscriptomicsMicroarray studies on effect of Pneumocystis carinii infection on global gene expression in alveolar macrophages
With a filter of false-discovery rate less than 0.1 and fold change greater than 1.5, 115 genes were found to be up- and 137 were down-regulated in alveolar macrophages during Pneumocystis carinii infection. Total RNA samples from 4 each of normal, dexamethasone-treated, and Pneumocystis carinii-inf...
ORGANISM(S): Rattus norvegicus 
2010-04-12 | E-GEOD-20149 | biostudies-arrayexpress
TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
TranscriptomicsTranscriptome-based network analysis reveals a spectrum model of human macrophage activation [miRNA-seq]
Macrophage activation is associated with profound transcriptional reprogramming. Although much progress has been made in the understanding of macrophage activation, polarization and function, the transcriptional programs regulating these processes remain poorly characterized. We stimulated human mac...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-51307 | biostudies-arrayexpress
GenomicsTranscriptome-based network analysis reveals a spectrum model of human macrophage activation [ChIP-Seq]
Macrophage activation is associated with profound transcriptional reprogramming. Although much progress has been made in the understanding of macrophage activation, polarization and function, the transcriptional programs regulating these processes remain poorly characterized. We stimulated human mac...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-47188 | biostudies-arrayexpress
TranscriptomicsKey Role of MicroRNA in the Regulation of Granulocyte Macrophage Colony-stimulating Factor Expression in Murine Alveolar Epithelial Cells (AEC) during Oxidative Stress
A genome wide microarray identified 19 candidate miRNA altered in primary AEC during oxidative stress with reversal by treatment with GM-CSF. Three of these microRNA (miR 133a, miR133a* and miR133b) are also predicited to bind the GM-CSF 3 UTR. 4 samples. Primary murine alveolar epithelial cells wer...
ORGANISM(S): Mus musculus 
2014-04-11 | E-GEOD-56687 | biostudies-arrayexpress
ProteomicsCigarette smoke extract-treated alveolar macrophage-derived extracellular vesicles
This project is based upon the fundamental observation that alveolar macrophage-derived extracellular vesicles (AM-EVs), when internalized by neighboring epithelial cells, inhibit their infection by influenza virus. This inhibitory activity of AM-EVs is abolished when AMs are treated with cigarette ...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-09 | PXD019528 | Pride
Extracellular vesicle Alveolar macrophage Cigarette smoke 
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