Alzheimer's disease model

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Mus musculus (230)
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Rheumatoid arthritis disease specific synovial fluid (1)
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Disease

Alzheimer's disease (121)
Parkinson's disease (6)
Alzheimer's disease 1 (4)
Tauopathy (3)
Disease free (3)
Huntington's disease (2)
Prion disease (2)
Down syndrome (2)
Frontotemporal dementia (2)
Cataract (1)
Autistic disorder (1)
Cardiovascular system disease (1)
Cancer (1)
Multiple sclerosis (1)
Alzheimer's disease 4 (1)
Hydrocephalus (1)
Alzheimer's disease 3 (1)
Disease (1)
Dementia (1)

Technology Type

Mass Spectrometry (159)
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Bottom-up proteomics (42)
Data-dependent acquisition (20)
Data-independent acquisition (20)
Mass spectrometry (8)
SWATH MS (8)
Gel-based experiment (6)
Affinity purification coupled with mass spectrometry proteomics (6)
HDMSE (4)
Top-down proteomics (4)
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Mass spectrometry assay (2)
NMR spectroscopy assay (1)
NMR spectroscopy (1)
DiaPASEF (1)
All-ion fragmentation (1)

Instrument Platform

Q Exactive (6)
Liquid Chromatography MS - negative - reverse phase (4)
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Illumina HiSeq 2500 (3)
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TripleTOF 6600 (2)
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Liquid Chromatography MS - negative - hilic (2)
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Publication Date

2025 (105)
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2015 (36)
2016 (25)
2020 (23)
2019 (21)
2014 (18)
2017 (17)
2018 (16)
2013 (15)
2012 (7)
2010 (6)
2009 (4)
2008 (4)
2011 (3)
2007 (3)
2006 (2)
2005 (1)

UNIPROT ID/AC

P05067 (13)
P49841 (4)
P04637 (4)
P62136 (3)
Q00987 (3)
Q9NZ42 (3)
Q13315 (3)
P0CG47 (2)
P08473 (2)
P10636 (2)
P50148 (2)
P56817 (2)
Q07954 (2)
P02649 (2)
Q7KYZ4 (1)
O95816 (1)
Q16543 (1)
Q71U36 (1)
P10145 (1)
P11142 (1)
P19174 (1)
P78352 (1)
Q13554 (1)
P50391 (1)
Q03169 (1)
P17861 (1)
Q13018 (1)
P04628 (1)
Q06787 (1)
P41221 (1)

ENSEMBL ID

ENSMUSG00000027651 (1)
ENSMUSP00000141097 (1)

CHEBI ID

CHEBI:15422 (11)
CHEBI:16761 (10)
CHEBI:16027 (6)
CHEBI:60425 (4)
CHEBI:26523 (4)
CHEBI:17822 (4)
CHEBI:16811 (4)
CHEBI:17230 (4)
CHEBI:17287 (4)
CHEBI:29101 (3)
CHEBI:16474 (3)
CHEBI:16526 (3)
CHEBI:15361 (3)
CHEBI:18021 (3)
CHEBI:16908 (3)
CHEBI:15355 (3)
CHEBI:16991 (3)
CHEBI:64645 (2)
CHEBI:27354 (2)
CHEBI:37455 (2)
CHEBI:15356 (2)
CHEBI:15740 (2)
CHEBI:17634 (2)
CHEBI:18237 (2)
CHEBI:26689 (2)
CHEBI:5656 (2)
CHEBI:16004 (2)
CHEBI:25523 (2)
CHEBI:17138 (2)
CHEBI:1989 (2)

Metabolite Name

Isocaproate (3)
Leucine (3)
Glycine (3)
Creatine (3)
Taurine (3)
3-methyvalerate (2)
2-methybutyrate (2)
Isobuturate (2)
2-hydroxybutyrate (2)
Butyrate (2)
Propionate (2)
Valerate (2)
Isovalerate (2)
Sarcosine (2)
Acetate (2)
Betaine (2)
Choline (2)
Pyruvate (2)
Tyrosine (2)
Serine (2)
Valine (2)
Alanine (2)
Lactose (2)
Galactitol (2)
ATP (2)
L-Leucine (2)
Threonine (2)
Succinate (2)
Proline (2)
Phenylalanine (2)

First Public Date

2025 (94)
2026 (74)
2024 (66)
2023 (43)
2022 (24)
2021 (21)
2020 (17)
2014 (15)
2017 (13)
2019 (11)
2015 (9)
2018 (8)
2016 (7)
2013 (1)

Modelling Approach

Ordinary differential equation model (28)
Machine learning (1)
Pharmacodynamics model (1)
Constraint-based model (1)

Lab affiliation

Federal University of Uberlandia (3)
Department of Neurology, Yale School of Medicine, Yale University, new haven CT, USA (3)
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark (3)
DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (3)
St Jude Children's Research Hospital (3)
Departments of Biochemistry and Neurology Emory University School of Medicine (2)
Room 6313, Academic building, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (2)
Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China. (2)
The Drug Discovery Lab, Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA (2)
Center for Neurogenomics and Cognitive Research, Department of Molecular and Cellular Neurobiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. (2)
Queensland Brain Institute, The University of Queensland, St Lucia Campus (Brisbane), QLD 4072, Australia (2)
DZNE Munich Neuroproteomics Feodor-Lynen Str. 17 81377 Munich Germany (2)
DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (2)
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario M5T2S8, Canada. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S1A8, Canada (2)
Istituto di Biomedicina ed Immunologia Molecolare (IBIM) CNR, Via U. La Malfa 153, Palermo 90146, Italy (1)
State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau 999078 (1)
Associate Professor, Department of Chemistry, Vanderbilt University (1)
Department of Neuropathology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany (1)
Traumatic Brain Injury Research, Roskamp Institute, Sarasota, FL, USA (1)
Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, Australia (1)
Roskamp Institute, Neurodegenerative Disease and Proteomics Lab, Sarasota, FL (1)
State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau (1)
1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 (1)
Instituto Carlos Chagas, FIOCRUZ, Curitiba, PR, Brazil (1)
University of Southern Denmark, department of biochemistry and molecular biology, Protein research group, Denmark (1)
Director, Institute for Tissue Engineering and Regenerative Medicine (iTERM) Helmholtz Zentrum München Ingolstädter Landstraße 1 85764 Neuherberg Germany (1)
Case Western Reserve University - Department of Pathology, School of Medicine (1)
Department of Pharmaceutical Biosciences Uppsala University (1)
Department of Neurobiology, School of Biology/Chemistry, Osnabrück University, Germany. Center for Cellular Nanoanalytics, Osnabrück University, Germany. Institute of Cognitive Science, Osnabrück University, Germany. (1)
Karolinska Institutet, Center for Alzheimer Research, Dept of Neurobiology, Care Sciences and Society, 141 57, Huddinge, Sweden (1)

IsPrivate

False (32)

Model Flag

Non Kinetic (2)

Submitter Keywords

Ersilia (1)
FAIR-AIML (1)
Machine Learning Model (1)

Study type

Transcription profiling by array (59)
RNA-seq of coding RNA (10)
ChIP-seq (3)
Methylation profiling by array (3)
Animal - High-throughput sequencing (2)
Animal - One-color microarray (1)
ChIP-chip by tiling array (1)
Comparative genomic hybridization by array (1)
Single nucleus RNA sequencing (1)
Proteomic profiling by array (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of total RNA (1)

Release Date

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2024 (1084)
2021 (954)
2020 (771)
2019 (559)
2018 (491)
2017 (394)
2016 (306)
2015 (295)
2014 (237)
2026 (159)
2013 (136)
2012 (118)
2011 (71)
2010 (70)
2009 (55)
2008 (37)
2007 (18)
2006 (15)
2005 (12)
2004 (11)
2003 (5)
2001 (5)
2002 (1)
1999 (1)

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Exploring the effects of acupuncture intervention on the gut microbiota of SAMP8 mice, a model of Alzheimer's disease.

2026-02-26 | MTBLS13601 | MetaboLights

Determination and comparison of SCFAs in serum and colon content samples: Alzheimer's disease rat as a case study (Method validation)

SCFAs are the main microbial fermentation products from dietary fibers in colon and play a key role in keeping healthy in the whole-body. However, differences of SCFAs concentration in the serum and colon samples collected from rats had attracted few attentions. Here, we optimized the extract and...

2020-11-24 | MTBLS2146 | MetaboLights

Determination and comparison of SCFAs in serum and colon content samples: Alzheimer's disease rat as a case study (SCFA serum and colon content determination)

2020-11-24 | MTBLS2088 | MetaboLights

Expression data from WT and TREM2 deficient microglia in a mouse model of Alzheimer's disease

We examined the role of TREM2 on microglia responses to amyloid-beta deposition in a mouse model of Alzheimer's disease Microglia were FACS-purified from 8.5 month old WT, Trem2-/-, 5XFAD, and Trem2-/- 5XFAD mice

ORGANISM(S): Mus musculus

2015-03-13 | E-GEOD-65067 | biostudies-arrayexpress

Neuronal Hyperactivity due to Loss of Inhibitory Tone in APOE4 Mice Lacking Alzheimer’s Disease-like Pathology

Metabolite profiling was performed on metabolites extracted from the entorhinal cortex and primary visual cortex of 14-15 month old APOE3/3, APOE3/4 and APOE4/4 mice. Metabolites were run on a TOF Mass Spectrometer using an ANP column. Initial analysis was done in an untargeted manner, and processin...

2017-09-05 | MTBLS530 | MetaboLights

5-Hydroxymenthylation-associated Epigenetic Modifiers in Alzheimer's disease

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive deterioration of cognitive function. Evidence suggests a role for epigenetic regulation, in particular the cytosine modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC,) in AD. 5hmC is hi...

ORGANISM(S): Homo sapiens

2016-07-20 | E-GEOD-72782 | biostudies-arrayexpress

Alzheimer's Disease Dataset

FK506 binding protein 51kDa (FKBP51/FKBP5) is part of a mature heat shock protein 90kDa (Hsp90) chaperone complex that preserves tau. Microarray analysis of human brains reveal that FKBP51 gene expression selectively increased with age and Alzheimer's disease, which correlated with demethylation of ...

ORGANISM(S): Homo sapiens

2014-04-21 | E-GEOD-48350 | biostudies-arrayexpress

Conserved epigenomic signatures between mouse and human elucidate immune basis of Alzheimer's disease

Alzheimer’s disease (AD) is a severe1 age-related neurodegenerative disorder characterized by accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during ne...

ORGANISM(S): Mus musculus

2015-02-18 | E-GEOD-65159 | biostudies-arrayexpress

Acutely isolated murine cortical astrocytes and microglia: Alzheimer's disease vs wildtype- effect of gfap-/- and vim-/-

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Reactive astrocytes with an increased expression of intermediate filament (IF) proteins Glial Fibrillary...

ORGANISM(S): Mus musculus

2015-11-04 | E-GEOD-74614 | biostudies-arrayexpress

Alzheimer's model and vitamin D

Little is known about the global molecular changes leading to neurodegeneration and brain dysfunction in Alzheimer's disease (AD). To study the molecular cascades involved, we chose to study the transcriptomic profile of an early-onset AD model, the 5xFAD mice, at different time points (1 month, 4 m...

ORGANISM(S): Mus musculus

2014-04-30 | E-MTAB-1937 | biostudies-arrayexpress

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