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TranscriptomicsGlobal Gene Expression analysis of CUTLL1 cell lines after treatment with Perhexiline
We identify perhexiline, a small molecule inhibitor of mitochondrial carnitine palmitoyltransferase-1, as a HES1-signature antagonist drug with robust antileukemic activity against NOTCH1 induced leukemias in vitro and in vivo. RNA-Seq from CUTLL1 cell lines treated with Perhexiline or vehicle for 3...
ORGANISM(S): Homo sapiens 
2015-05-07 | E-GEOD-66014 | biostudies-arrayexpress
TranscriptomicsExpression data from Hes1 conditional knock-out NOTCH1-induced leukemias
To formally address the biological activity of Hes1 in vivo, we tested the interaction between oncogenic NOTCH1 and acute Hes1 loss in a retroviral-transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full leuk...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-65863 | biostudies-arrayexpress
TranscriptomicsExpression data from CUTLL1 cells infected with shHES1
To formally address the biological activity of HES1 in vitro, we measured the transcriptional effect of HES1 inactivation infectiing CUTLL1 leukemia cell lines with shHES1 HES1 knockdown triggered apoptosis in human T-ALL lymphoblasts. We show that HES1 inactivation induces programmed cell death in ...
ORGANISM(S): Homo sapiens 
2015-05-07 | E-GEOD-65872 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile of 53 human T-ALL samples collected in human clinical trial E2993 (Marks et al., 2009)
To analyze the prognostic relevance of transcriptional profiling in adult T-ALL, we analyzed a clinical series of 53 primary leukemia samples uniformly treated according to the ECOG E2993 protocol using gene expression oligonucleotide microarrays. Unsupervised analysis and consensus clustering of mi...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-42328 | biostudies-arrayexpress
TranscriptomicsExpression data from isogenic Pten WT or KO mouse T-ALLs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71090 | biostudies-arrayexpress
TranscriptomicsExpression data from Sh2b3 Knock-out NOTCH1-induced leukemias
To formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in a retroviral- transduction bone marrow transplantation model of NOTCH-induced T-ALL Forced expression of activated NOTCH1 in this model typically results in full l...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-44025 | biostudies-arrayexpress
TranscriptomicsExpression of DND41 cell lines treated with 1M-BM-5M Dexamethasone for 24h after shPTEN infection
Glucocorticoid resistance is a major driver of therapeutic failure in T-cell acute lymphoblastic leukemia (T-ALL). Here we identify the AKT1 kinase as a signaling factor driving glucocorticoid resistance in T-ALL. Mechanistically, AKT1 directly phosphorylates the glucocorticoid receptor NR3C1 protei...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-41062 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Early immature and Late mature T-ALL cell lines
Early immature T-cell acute lymphoblastic leukemias (T-ALLs) account for about 5-10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. Analysis of microarray gene expression signatures in adult T-AL...
ORGANISM(S): Homo sapiens 
2013-06-18 | E-GEOD-48046 | biostudies-arrayexpress
GenomicsNOTCH1 ChIP-Seq in HBPALL cell lines
ChIP-Seq detected global binding of NOTCH1 oncogene in a human T-Cell Leukemia Cell line. ChIP-Seq of NOTCH1 in HBALL cell lines and Whole Cell Extract (WCE) as control.
ORGANISM(S): Homo sapiens 
2014-09-07 | E-GEOD-58406 | biostudies-arrayexpress
TranscriptomicsExpression profiling of sorted human Thymocyte populations
Thymus samples were obtained as surgical tissue discards from 3 pediatric patients (age from 7 days to 6 months) undergoing cardiac surgery at the New York Presbyterian Hospital. RNA was excracted and processed for expression analysis from 7 isolated T-Cell populations. Gene expression analysis of 7...
ORGANISM(S): Homo sapiens 
2011-11-05 | E-GEOD-33470 | biostudies-arrayexpress
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