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ProteomicsProteomic sex determination vs osteological sex estimation – what effect do our techniques have on the way we view the people of the past?
Amelogenin, a protein involved in the formation of enamel occurs as two isoforms, AMEL X and AMEL Y, which are encoded on the X and Y chromosome respectively. Isoform-specific peptides can be used for the determination of the chromosomal sex in ancient teeth. This strategy was used to determine the ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-25 | PXD066946 | Pride
Chromosomal sex determination Amel y Amel x Amelogenin 
ProteomicsEnamel peptide analysis to determine chromosomal sex of human remains (kōiwi tangata) of Māori-era individuals from New Zealand (Aotearoa)
Amelogenin, a protein involved in the formation of enamel occurs as two isoforms, AMEL X and AMEL Y, which are encoded on the X and Y chromosome respectively. Isoform-specific peptides can be used for the determination of the chromosomal sex in ancient teeth. This strategy was used here to determine...
ORGANISM(S): Homo sapiens (Human) 
2026-01-14 | PXD065222 | Pride
Chromosomal sex determination of human remains Amilogenin 
UnknownSynergistic roles of amelogenin and ameloblastin.
Not available
S-EPMC2758615 | biostudies-literature
UnknownCo-Immunoprecipitation Reveals Interactions Between Amelogenin and Ameloblastin via Their Self-Assembly Domains.
Not available
S-EPMC7786100 | biostudies-literature
UnknownThe Evolution of Unusually Small Amelogenin Genes in Cetaceans; Pseudogenization, X-Y Gene Conversion, and Feeding Strategy.
Not available
S-EPMC9251807 | biostudies-literature
UnknownThe amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species.
Not available
S-EPMC154332 | biostudies-literature
UnknownComputational approach towards identification of pathogenic missense mutations in AMELX gene and their possible association with amelogenesis imperfecta.
Not available
S-EPMC7382399 | biostudies-literature
UnknownDiversification of Pakistani Amelogenin-Y-Null Male Haplotypes.
Not available
S-EPMC8116151 | biostudies-literature
UnknownA model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome.
Not available
S-EPMC3857954 | biostudies-literature
ProteomicsPhenotypic analysis of 5000 year-old human teeth using optimized large-scale and targeted proteomics approaches
Tooth is a remarkable source of information for paleoanthropologists. Investigation of ancient dental proteomes is able to provide biomolecular data helping at understanding past life. In particular, the enamel protein amelogenin (AMEL) offers the possibilty to determine the sex of the specimen. In ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-06 | PXD012481 | Pride
Amelogenin Collagene i(x) Prm Tooth Paleoproteomics Sex Genetically variant peptides Cementum protein 1 
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