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ProteomicsPersulfidome of A549 alveolar epithelial cells
To better define the relationship between persulfidation and the cellular antifungal response, we analyzed the cellular persulfidome (proteome of persulfidated proteins) in A549 and in CTH-/- cells upon challenge with Aspergillus fumigatus conidia and/or the sulfide donor GYY4137. All proteins were ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-17 | PXD076106 | Pride
Aspergillus fumigatus A549 persulfidome Gyy4137 persulfidome Cth-/- 
MetabolomicsTargeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence
There is an urgent need to develop novel antifungals to tackle the threat that fungal pathogens pose to human health. In this work, we have performed a thorough characterisation and validation of the promising target methionine synthase. We have uncovered that in Aspergillus fumigatus the absence of...
2020-10-15 | MTBLS1636 | MetaboLights
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