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ProteomicsRapid and accurate detection of aminoglycoside modifying enzymes and 16S ribosomal RNA methyltransferases by targeted LC-MS/MS
New and rapid diagnostic methods are needed for the detection of antimicrobial resistance to aid in the curbing of drug-resistant infections. Targeted LC-MS/MS is a method that could serve this purpose, as it can detect specific peptides of resistance mechanisms with high accuracy. In the current st...
ORGANISM(S): Escherichia coli Klebsiella pneumoniae BIDMC 40 
2021-04-30 | PXD024339 | Pride
E. coli Aminoglycosides Parallel reaction monitoring Aminoglycoside modifying enzymes Liquid chromatography mass spectrometry K. pneumoniae 16s ribosomal rna methyltransferases Antimicrobial resistance 
UnknownAminoglycoside modifying enzymes.
Not available
S-EPMC2992599 | biostudies-literature
UnknownPlazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.
Not available
S-EPMC6167752 | biostudies-literature
UnknownModifying enzymes related aminoglycoside: analyses of resistant Acinetobacter isolates.
Not available
S-EPMC4402895 | biostudies-literature
UnknownStrategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections.
Not available
S-EPMC3819198 | biostudies-literature
UnknownAminoglycoside-Modifying Enzymes Are Sufficient to Make Pseudomonas aeruginosa Clinically Resistant to Key Antibiotics.
Not available
S-EPMC9312099 | biostudies-literature
GenomicsCo-occurrence of aminoglycoside and beta-lactam resistance in E.coli
Co-occurrence of aminoglycoside and beta-lactam resistance in E.coli
PRJEB36139 | ENA
UnknownEcology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes.
Not available
S-EPMC9928423 | biostudies-literature
ProteomicsRapid detection of beta-lactam, aminoglycoside and fluoroquinolone resistance mechanisms in blood cultures positive for E. coli or K. pneumoniae using targeted LC-MS/MS
New and rapid antimicrobial susceptibility/resistance testing methods are required for bacteria from positive blood cultures. In the current study we developed and evaluated a targeted LC-MS/MS assay for the detection of beta-lactam, aminoglycoside and fluoroquinolone resistance mechanisms in blood ...
ORGANISM(S): Klebsiella pneumoniae JH1 Klebsiella variicola At-22 Acinetobacter sp. PM-14 Escherichia coli 
2022-07-01 | PXD025365 | Pride
Blood cultures Gyra E. coli Liquid chromatography-mass spectrometry Sepsis Qnr proteins Parallel reaction monitoring Aminoglycoside modifying enzymes K. pneumoniae 16s ribosomal rna methyltransferases Beta-lactamases Antimicrobial resistance 
UnknownArtemisinin derivative DHA27 enhances the antibacterial effect of aminoglycosides against Pseudomonas aeruginosa by inhibiting mRNA expression of aminoglycoside-modifying enzymes.
Not available
S-EPMC9637796 | biostudies-literature
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