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ProteomicsIdentification of β-lactamases produced by Enterobacteriaceae
The increasing spread of drug-resistant bacterial strains presents great challenges to clinical antibacterial treatment and public health, particularly with regard to β-lactamase-producing Enterobacteriaceae. A rapid and accurate detection method that can expedite precise clinical diagnosis and rati...
ORGANISM(S): Klebsiella pneumoniae ATCC BAA-2146 
2022-06-08 | PXD028791 | Pride
Β-lactamases Detection Enterobacteriaceae 
ProteomicsLC-MS/MS analysis demonstrates a decrease in porins and increase in CMY-2-like beta-lactamases in E. coli exposed to meropenem
While ESBL and AmpC beta-lactamases barely degrade carbapenems, they are able to bind them and prevent them from interacting with penicillin binding proteins thereby preventing their effect. When these beta-lactamases are expressed at a high level and combined with a decreased influx of carbapenems ...
ORGANISM(S): Escherichia coli 
2022-04-04 | PXD025363 | Pride
E. coli Cmy-2-like Liquid chromatography-mass spectrometry Ompc Meropenem Parallel reaction monitoring Chromosomal ampc Ompf Antimicrobial resistance 
ProteomicsMyxobacterial metallo-β-lactamases
Understanding the biology of B1 metallo-β-lactamases (MβLs) in their native hosts and the molecular bases of the adaptive mechanisms during the transfer process to human pathogens, may provide novel therapeutic insights against these important resistance factors. Through large scale phylogenomic ana...
ORGANISM(S): Myxococcales 
2026-05-20 | PXD077803 | Pride
Myx-2 Myx-1 Myxobacteria 
GenomicsIn vivo evolution of GES β-lactamases driven by ceftazidme/avibactam treatment of Pseudomonas aeruginosa infections
In vivo evolution of GES β-lactamases driven by ceftazidme/avibactam treatment of Pseudomonas aeruginosa infections
PRJEB44930 | ENA
GenomicsKlebsiella pneumoniae strain:GN4549
beta-lactamases in Jamaica
PRJNA861980 | ENA
GenomicsPerturbation and resilience of the gut microbiome three months after β-lactams exposure in healthy volunteers suggest an important role of endogenous β-lactamases
Perturbation and resilience of the gut microbiome three months after β-lactams exposure in healthy volunteers suggest an important role of endogenous β-lactamases
PRJEB58157 | ENA
UnknownStandard numbering scheme for class B beta-lactamases.
Not available
S-EPMC90352 | biostudies-literature
UnknownOXA β-lactamases.
Not available
S-EPMC3993105 | biostudies-literature
UnknownChromosome-Encoded Broad-Spectrum Ambler Class A β-Lactamase RUB-1 from Serratia rubidaea.
Not available
S-EPMC5278729 | biostudies-literature
TranscriptomicsBeneficial impact of acquired AmpC β-lactamases on bacterial fitness and pathogenicity: a new paradigm
The study investigated the impact of acquired AmpC β-lactamases on global gene expression and cellular physiology in Enterobacterales. Isogenic Escherichia coli MG1655 strains carrying empty vector (p0) or plasmids encoding CMY-2, CMY-42, or CMY-145 β-lactamase variants were grown to mid-log phase i...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2026-03-24 | GSE311194 | GEO
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