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MetabolomicsLeucine degradation metabolite ratio as a measure of meropenem susceptibility in carbapenem-resistant Klebsiella pneumoniae

Rapid detection of carbapenem-resistant Klebsiella pneumoniae (CRKP) is essential for effective clinical management and surveillance. This study investigated volatile organic compounds (VOCs) as phenotypic biomarkers of carbapenem resistance, with the goal of developing a translationally...

2026-06-09 | MTBLS13539 | MetaboLights
GenomicsWhole genome TraDIS-Xpress assay to determine gene roles during growth of E. coli in different concentrations of the beta-lactam antibiotic meropenem
The aim of the experiment was to assay every gene in the E. coli genome to identify those that contribute to increased or decreased susceptibility to the beta-lactam antibiotic meropenem. A library of transposon-insertion mutants was grown overnight in the presence or absence of a range of concentra...
ORGANISM(S): Escherichia coli K-12 
2022-06-09 | E-MTAB-11802 | biostudies-arrayexpress
ProteomicsMulti-omics, multi assay analysis of evolved resistance to ceftazidime-avibactam in Pseudomonas aeruginosa, compared to meropenem resistance and co-resistance evolution
Pseudomonas aeruginosa is a major cause of infection in hospitalised patients, with a large genome which makes it highly versatile and resistant to most antimicrobial agents. Ceftazidime-avibactam (CZA) offers an alternative treatment, but resistance is quickly evolving. There is limited knowledge ...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-05-21 | PXD044998 | Pride
Proteomics Crispr/cas9 Ceftazidime-avibactam Resistance mechanism Pseudomonas aeruginosa Genomics Transcriptomics Dacb Meropenem 
ProteomicsLC-MS/MS analysis demonstrates a decrease in porins and increase in CMY-2-like beta-lactamases in E. coli exposed to meropenem
While ESBL and AmpC beta-lactamases barely degrade carbapenems, they are able to bind them and prevent them from interacting with penicillin binding proteins thereby preventing their effect. When these beta-lactamases are expressed at a high level and combined with a decreased influx of carbapenems ...
ORGANISM(S): Escherichia coli 
2022-04-04 | PXD025363 | Pride
E. coli Cmy-2-like Liquid chromatography-mass spectrometry Ompc Meropenem Parallel reaction monitoring Chromosomal ampc Ompf Antimicrobial resistance 
ProteomicsProteomic Profile of multidrug- resistant Serratia marcescens under meropenem challenge
The study consists of analyzing the proteomic profile of a multiresistant bacterial strain, Serratia marcescens (Sm36), after it is challenged to grow in an environment in the presence of Meropenem, an antimicrobial considered broad-spectrum and widely used for the treatment of Healthcare-Associated...
ORGANISM(S): Serratia marcescens 
2025-01-03 | PXD059425 | Pride
Virulence  bacteria  proteomics  multidrug resistance  meropenem 
GenomicsKlebsiella pneumoniae strain:Isolated from meropenem treated soil | isolate:Isolated from meropenem treated soil
Klebsiella pneumoniae strain:Isolated from meropenem treated soil | isolate:Isolated from meropenem treated soil Genome sequencing
PRJNA681347 | ENA
ProteomicsThe proteomic responses of carbapenemase-producing and non-producing carbapenem-resistant Pseudomonas aeruginosa strains to subminimal-inhibitory concentrations of meropenem revealed by quantitative tandem mass spectrometry
Pseudomonas aeruginosa is a major opportunistic pathogen causing a wide range of infections and one of the most problematic bacteria regarding antibiotic resistance, with an increasing incidence of multidrug and extensively-drug resistant strains, including resistance to last resource antibiotics su...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD034987 | Pride
Multidrug resistance High-risk clones Opportunistic pathogen Antibiotic resistance Tandem mass spectrometry Tandem mass tag (tmt) Quantitative proteomics Carbapenem Pseudomonas aeruginosa Meropenem Antimicrobial resistance Lc-ms/ms 
GenomicsE. coli isolates meropenem resistant
LC-MS/MS analysis demonstrates a decrease in porins and increase in CMY-2-like beta-lactamases in E. coli exposed to meropenem
PRJEB44241 | ENA
GenomicsMulti-omics informed mathematical model for meropenem and tobramycin against hypermutable Pseudomonas aeruginosa
Multi-omics informed mathematical model for meropenem and tobramycin against hypermutable Pseudomonas aeruginosa
PRJEB79131 | ENA
TranscriptomicsTranscriptional changes between mono- and dual-species biofilms of Pseudomonas aeruginosa and Candida albicans, ± meropenem treatment
The goals of this dual-seq experiment were to 1) identify transcriptional changes between mono-species and dual-species biofilms of Candida albicans and Pseudomonas aeruginosa and 2) identify transcriptional changes within mono- or dual-species P. aeruginosa biofilm cells in response to meropenem tr...
ORGANISM(S): Pseudomonas aeruginosa Candida albicans 
2022-11-11 | GSE167137 | GEO
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