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ProteomicsLC-MS/MS analysis demonstrates a decrease in porins and increase in CMY-2-like beta-lactamases in E. coli exposed to meropenem
While ESBL and AmpC beta-lactamases barely degrade carbapenems, they are able to bind them and prevent them from interacting with penicillin binding proteins thereby preventing their effect. When these beta-lactamases are expressed at a high level and combined with a decreased influx of carbapenems ...
ORGANISM(S): Escherichia coli 
2022-04-04 | PXD025363 | Pride
E. coli Cmy-2-like Liquid chromatography-mass spectrometry Ompc Meropenem Parallel reaction monitoring Chromosomal ampc Ompf Antimicrobial resistance 
GenomicsE. coli isolates meropenem resistant
LC-MS/MS analysis demonstrates a decrease in porins and increase in CMY-2-like beta-lactamases in E. coli exposed to meropenem
PRJEB44241 | ENA
UnknownDevelopment of Nanobodies as Theranostic Agents against CMY-2-Like Class C β-Lactamases.
Not available
S-EPMC10112224 | biostudies-literature
UnknownHydrolysis spectrum extension of CMY-2-like β-lactamases resulting from structural alteration in the Y-X-N loop.
Not available
S-EPMC3294937 | biostudies-literature
UnknownCMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids.
Not available
S-EPMC2650574 | biostudies-literature
UnknownEvolution and spread of a multidrug-resistant Proteus mirabilis clone with chromosomal AmpC-type cephalosporinases in Europe.
Not available
S-EPMC3101460 | biostudies-literature
ProteomicsRapid detection of beta-lactam, aminoglycoside and fluoroquinolone resistance mechanisms in blood cultures positive for E. coli or K. pneumoniae using targeted LC-MS/MS
New and rapid antimicrobial susceptibility/resistance testing methods are required for bacteria from positive blood cultures. In the current study we developed and evaluated a targeted LC-MS/MS assay for the detection of beta-lactam, aminoglycoside and fluoroquinolone resistance mechanisms in blood ...
ORGANISM(S): Klebsiella pneumoniae JH1 Klebsiella variicola At-22 Acinetobacter sp. PM-14 Escherichia coli 
2022-07-01 | PXD025365 | Pride
Blood cultures Gyra E. coli Liquid chromatography-mass spectrometry Sepsis Qnr proteins Parallel reaction monitoring Aminoglycoside modifying enzymes K. pneumoniae 16s ribosomal rna methyltransferases Beta-lactamases Antimicrobial resistance 
UnknownIn Vivo Evolution of CMY-2 to CMY-33 β-Lactamase in Escherichia coli Sequence Type 131: Characterization of an Acquired Extended-Spectrum AmpC Conferring Resistance to Cefepime.
Not available
S-EPMC4649241 | biostudies-literature
UnknownComplete sequencing of IncI1 sequence type 2 plasmid pJIE512b indicates mobilization of blaCMY-2 from an IncA/C plasmid.
Not available
S-EPMC4135994 | biostudies-literature
UnknownCMY-16, a novel acquired AmpC-type beta-lactamase of the CMY/LAT lineage in multifocal monophyletic isolates of Proteus mirabilis from northern Italy.
Not available
S-EPMC1366893 | biostudies-literature
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