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MetabolomicsLeucine degradation metabolite ratio as a measure of meropenem susceptibility in carbapenem-resistant Klebsiella pneumoniae

Rapid detection of carbapenem-resistant Klebsiella pneumoniae (CRKP) is essential for effective clinical management and surveillance. This study investigated volatile organic compounds (VOCs) as phenotypic biomarkers of carbapenem resistance, with the goal of developing a translationally...

2026-06-09 | MTBLS13539 | MetaboLights
MetabolomicsSerum Proteomic and Metabolomic Profiling of Sepsis Patients Reveals a Diagnostic Model and Mechanistic Insights into Carbapenem-Resistant Klebsiella pneumoniae Infection

Serum Proteomic and Metabolomic Profiling of Sepsis Patients Reveals a Diagnostic Model and Mechanistic Insights into Carbapenem-Resistant Klebsiella pneumoniae Infection

2026-05-18 | MTBLS14016 | MetaboLights
MetabolomicsExogenous glutamate potentiates gentamicin to kill multidrug- and carbapenem-resistant Pseudomonas aeruginosa through activating biosynthesis of unsaturated fatty acids

Antibiotic-resistant Pseudomonas aeruginosa is a major clinical challenge due to limited drug uptake. This study shows that exogenous glutamate restores gentamicin efficacy by reprogramming bacterial metabolism to enhance membrane permeability. The effect is mediated through increased biosynthesi...

2025-09-22 | MTBLS12656 | MetaboLights
ProteomicsProteomic analysis of carbapenem-resistant Klebsiella pneumoniae exposure to tigecycline and aminoglycosides
Proteomic analysis of carbapenem-resistant Klebsiella pneumoniae exposure to tigecycline and aminoglycosides
ORGANISM(S): Klebsiella Pneumoniae Subsp. Pneumoniae Hs11286 
2022-01-17 | PXD031030 |
TranscriptomicsCharacterization of cefiderocol heteroresistance in carbapenem-resistant Acinetobacter baumannii (CRAB) cells after exposure to Human Pleural Fluid (HPF)
Objectives: Carbapenem-resistant Acinetobacter baumannii (CRAB) are one of the most difficult pathogen to treat. The only drug recently approved by the FDA that is active against CRAB is cefiderocol. However, recent studies have shown higher all-cause mortality rate in the group of patients treated ...
ORGANISM(S): Acinetobacter baumannii 
2023-03-31 | E-MTAB-12444 | biostudies-arrayexpress
ProteomicsOuter membrane vesicles of clinical tet(x3), blaNDM-1, and blaOXA-97-carrying Acinetobacter baumannii isolates contribute to carbapenem resistance
Infections caused by carbapenem-resistant Acinetobacter baumannii (CRAb) are associated with high patient morbidity and mortality. The serious threat for human health imposed by CRAb was recently underscored by identification of close-to-untouchable carbapenem- and tetracycline-resistant isolates. S...
ORGANISM(S): Acinetobacter baumannii 
2025-04-14 | PXD051698 | Pride
Acinetobacter baumannii Outer membrane vesicles Carbapenem Tetracyclin Antibiotic resistance 
TranscriptomicsComprehensive Assessment of Initial Adaptation of ESBL Positive ST131 E. coli to Carbapenem Exposure
Background: It remains unclear how high-risk Escherichia coli lineages, like sequence type (ST) 131, initially adapt to carbapenem exposure in its progression to becoming carbapenem resistant. Methods: Carbapenem mutation frequency was measured in multiple subclades of extended-spectrum β-lactamase ...
ORGANISM(S): Escherichia coli 
2024-08-04 | GSE273456 | GEO
GenomicsCarbapenem-Resistant Organisms (CRO)
Carbapenem-Resistant Organisms (CRO) Raw sequence reads
PRJNA1358945 | ENA
GenomicsCarbapenem-resistant Enterobacteriaceae spp.
Carbapenem-resistant Enterobacteriaceae spp.Genome sequencing and assembly
PRJNA1135755 | ENA
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
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