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GenomicsA negative feedback loop of transcription factors specifies alternative dendritic cell chromatin states (ChIP-Seq)
During hematopoiesis, cells originating from the same stem cell reservoir differentiate into distinct cell types. The mechanisms enabling common progenitors to differentiate into distinct cell fates are not fully understood. Here, we identify chromatin-regulating and cell-fate-determining transcript...
ORGANISM(S): Mus musculus 
2014-12-11 | E-GEOD-62702 | biostudies-arrayexpress
TranscriptomicsDendritic cell stimulation: 5 ligands, 9 time points
mouse primary BMDCs were stimulated with tlr ligands and gene expression changes were profiled on Affymetrix arrays BMDC were stimulated with 5 tlr ligands (LPS, pIC ,PAM, CpG, GRD) across 9 time points (.5, 1, 2, 4, 6, 8, 12, 16, 24 hours). Unstimulated cells were used as controls.
ORGANISM(S): Mus musculus 
2010-06-21 | E-GEOD-17721 | biostudies-arrayexpress
TranscriptomicsA negative feedback loop of transcription factors specifies alternative dendritic cell chromatin states (RNA-Seq)
During hematopoiesis, cells originating from the same stem cell reservoir differentiate into distinct cell types. The mechanisms enabling common progenitors to differentiate into distinct cell fates are not fully understood. Here, we identify chromatin-regulating and cell-fate-determining transcript...
ORGANISM(S): Mus musculus 
2014-12-14 | E-GEOD-62704 | biostudies-arrayexpress
TranscriptomicsMassively parallel single-cell RNA-Seq for dissecting cell type and cell state compositions
In multi-cellular organisms, biological function emerges when cells of heterogeneous types and states are combined into complex tissues. Nevertheless unbiased dissection of tissues into coherent cell subpopulations is currently lacking. We introduce an automated, massively parallel single cell RNA s...
ORGANISM(S): Mus musculus 
2014-02-14 | E-GEOD-54006 | biostudies-arrayexpress
Proteomics,MultiomicsSystematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10...
2013-12-10 | MSV000078507 | MassIVE
TranscriptomicsTissue-resident macrophage enhancer landscapes are shaped by the local microenvironment [RNA-seq]
Macrophages are hematopoietic cells critical for innate immune defense, but also control organ homeostasis in a tissue-specific manner. Tissue-resident macrophages, therefore, provide a well-defined model to study the impact of ontogeny and microenvironment on chromatin state. Here, we profile the d...
ORGANISM(S): Mus musculus 
2014-12-05 | E-GEOD-63340 | biostudies-arrayexpress
TranscriptomicsTissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-12-05 | E-GEOD-63341 | biostudies-arrayexpress
TranscriptomicsDistinct murine mucosal Langerhans cell subsets develop from pre-DCs and monocytes
Langerhans cells (LCs) populate the mucosal epithelium, a major entry portal for pathogens, yet their ontogeny remains unclear. In contrast to skin LCs originating from self-renewing radioresistant embryonic precursors, we found that oral mucosal LCs derive from circulating radiosensitive precursors...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-68789 | biostudies-arrayexpress
GenomicsChromatin state dynamics during blood formation (ChIP-Seq)
We develop a new ChIpseq method (iChIP) to profile chromatin states of low cell number samples. We use IChIP to profile the chromatin dynamics during hematopoiesis across 16 different cell types which include the principal hematopoietic progenitors Examination of 2 different histone modifications in...
ORGANISM(S): Mus musculus 
2014-08-08 | E-GEOD-59636 | biostudies-arrayexpress
GenomicsHES1 ChIP-seq in human embryonic stem cell derived pancreas progenitors Day 13.
To identify genome-wide, direct targets of HES1 in human pancreas progenitors, we performed Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) of endogenous HES1 in the HUES4 PDX1GFP/+ reporter cell line on Day 13 of differentiation from both unsorted bulk populations and FACS-sort...
ORGANISM(S): Homo sapiens 
2022-02-27 | E-MTAB-6922 | biostudies-arrayexpress
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