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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
TranscriptomicsGSK-3A and GSK-3B knockdown in AML cell lines
Gene expression data from AML cell lines, MOLM-14, U937, THP-1 and HL-60, that were infected with a scrambled control hairpin (shControl), two shRNAs directed against GSK-3B (shGSK3B_1 and shGSK3B_2), or two shRNAs directed against GSK-3A (shGSK3A_5 and shGSK3A_6). Acute myeloid leukemia (AML) is th...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-35200 | biostudies-arrayexpress
ProteomicsSynergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia
Acute Myeloid Leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases FLT3 and KIT. FLT3 and KIT mutations are associated with poor...
ORGANISM(S): Mus Musculus 
2023-01-26 | PXD030214 | panorama
TranscriptomicsExpression profiling of murine hemopoietic cell survival on oligo arrays.
Deregulated cell survival programs are a classical hallmark of cancer. We have previously identified a serine residue (Ser585) in the beta-c subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor that selectively and independently promotes cell survival. We now show that S...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-18220 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine hemopoietic cell survival on cDNA arrays.
Deregulated cell survival programs are a classical hallmark of cancer. We have previously identified a serine residue (Ser585) in the beta-c subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor that selectively and independently promotes cell survival. We now show that S...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-18221 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human blood from acute promyelocytic leukemia patients using different differentiating agents
Differentiating agents have been proposed to overcome the impaired cellular differentiation in acute myeloid leukemia (AML). However, only the combinations of all-trans retinoic acid or arsenic trioxide with chemotherapy have been successful, and only in treating acute promyelocytic leukemia (also c...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-TABM-925 | biostudies-arrayexpress
ProteomicsChemical phosphoproteomics reveals kinase network topologies associated to genotypes and phenotypes of cancer cells.
We compare the in vitro specificity profiles of several kinase inhibitors with their effects on cellular phosphoproteomes. For this aim, we developed an algorithm which utilizes information on kinase inhibitor selectivity to determine the most probable kinase(s) acting upstream of phosphorylation si...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-22 | MSV000090571 | MassIVE
ProteomicsProteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia
Label-free quantitation dataset from 44 representative Acute Myeloid Leukemia (AML) patients from the LAML TCGA dataset, and 6 healthy bone marrow derived controls including 3 lineage-depleted and 3 CD34+ selected bone marrows.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089029 | MassIVE
ProteomicsProteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia
A deep-scale proteome and phosphoproteome database from 44 representative Acute Myeloid Leukemia (AML) patients from the LAML TCGA dataset, and 6 healthy bone marrow derived controls including 3 lineage-depleted and 3 CD34+ selected bone marrows.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-07 | MSV000089012 | MassIVE
ProteomicsPhosphoproteomic characterization of primary AML samples and relevance for response towards FLT3-inhibitors
Kinase hyperactivity is a common driver of acute myeloid leukemia (AML) and serves as a therapeutic target. The most frequent genetic aberration leading to hyperactive kinase signaling and poor prognosis is internal tandem duplication (ITD) of the FMS-tyrosine-like Kinase 3-gene (FLT3). FLT3-ITD ind...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024235 | Pride
Aml Imac Gilteritinib Flt3 Midostauri Ptyr Label-free Phosphoproteomics 
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