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TranscriptomicsTranscriptional profiling of Acute Myeloid Leukaemia (AML) cells following co-culture with anti-CD44. RNA-seq of anti-CD44 treated, paired, attached, detached and cells in monoculture using two AML cell lines, KG1a and OCI-AML3
Although 80% of AML patients can initially achieve a complete remission, the long-term disease-free survival is only 40% at 6 years with a 10% 5-year survival rate from first relapse. Most patients do not achieve a second remission. Therefore, relapse after initial response to chemotherapy remains a...
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-14052 | biostudies-arrayexpress
ProteomicsExtracellular vesicles impose quiescence and confer DNA-damage on residual HSC in the AML niche
To understand the mechanism by which AML-EVs may enforce quiescence, we performed tandem mass tag (TMT) proteomic profiling of in vitro cultured c-Kit+ hematopoietic stem and progenitor cells (HSPC) (to obtain the minimum required amount of protein lysates) treated with extracellular vesicles (EVs) ...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-24 | PXD013688 | Pride
Aml-derived extracellular vesicles Isobaric labeling Proteomics Bone marrow Acute myeloid leukemia (aml) Mouse Tandem mass tags 
ProteomicsBone Marrow Mesenchymal Stromal Cells Support Translation in Refractory Acute Myeloid Leukemia
In acute myeloid leukemia (AML), malignant cells surviving chemotherapy rely on high mRNA translation and their microenvironmental metabolic support to drive relapse. However, the role of translational reprogramming in the niche is unclear. Here we found that relapsing AML cells increase translation...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-12-27 | PXD058646 | Pride
Aml niche Translational reprogramming 
Genomics
Identifing AML niche
PRJNA1077712 | ENA
UnknownTreatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML.
Not available
S-EPMC8351342 | biostudies-literature
UnknownProtein tyrosine kinase 2b inhibition reverts niche-associated resistance to tyrosine kinase inhibitors in AML.
Not available
S-EPMC9522596 | biostudies-literature
GenomicsBulk and single-cell AML RNA-seq post ex vivo culture
Bulk and single-cell RNA-seq performed on primary AML blasts cultured ex vivo for 3 days in standard or niche-like conditions.
EGAS00001006265 | EGA
UnknownA Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML.
Not available
S-EPMC10472197 | biostudies-literature
ProteomicsIn-Depth Proteomics Reveals Selective EV Protein Sorting and Pathway Perturbation in AML upon Synergistic FLT3 and Hedgehog Pathway Inhibition
Acute myeloid leukemia (AML) is an aggressive cancer mainly affecting bone marrow and blood with a high relapse incidence and mortality rate. Approximately one third of AML patients carry an fms-like tyrosine kinase 3 (FLT3) mutation, which is often associated with GLI expression and Hedgehog signal...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD061404 | Pride
Hpi-1 Proteomics Erbb signaling Evs Crenolanib Ribosomal proteins Aml 
GenomicsIdh1-R132H mutation increases murine hematopoietic progenitors and alters epigenetics.
Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequent in human glioblastomas1 and cytogenetically normal acute myeloid leukemias (AML)2. These alterations are gain-of-function mutations in that they drive the synthesis of the M-bM-^@M-^\oncometaboliteM-bM-^@M-^] R-2-hy...
ORGANISM(S): Mus musculus 
2012-07-22 | E-GEOD-38687 | biostudies-arrayexpress
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