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TranscriptomicsThe conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells
Different from canonical ubiquitin-like proteins, Hub1 does not form covalent conjugates with substrates but binds proteins non-covalently. In Saccharomyces cerevisiae, Hub1 associates with spliceosomes and mediates alternative splicing of SRC1, without affecting pre-mRNA splicing generally. Human H...
ORGANISM(S): Homo sapiens 
2014-05-30 | E-GEOD-56878 | biostudies-arrayexpress
TranscriptomicsSIV Encephalitis and Uninfected Control: Hippocampus Expression Profiles
HIV-associated dementia (HAD) is a syndrome occurring in HIV-infected patients with advanced disease that likely develops as a result of macrophage and microglial activation as well as other immune events triggered by virus in the central nervous system. The most relevant experimental model of HAD, ...
ORGANISM(S): Macaca mulatta 
2010-04-03 | E-GEOD-13824 | biostudies-arrayexpress
TranscriptomicsExpression data from fetal sheep immunocytes
study investigating the initiation of systemic inflammatory signaling in fetuses exposed to TLR-4 agonist lipopolysaccharides from E.coli microarray was used to determine the inflammatory transcriptome in circulating fetal immunocytes fetal sheep at 92d GA were catheterised prior to intraamniotic ex...
ORGANISM(S): Ovis aries 
2015-08-21 | E-GEOD-72240 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of WT and Mecp2 KO hippocampus after transplantation with Neural/Precursor Cells (NPCs)
RTT represents the first genetic cause of severe intellectual disability in girls and although potentially treatable, no cure is currently available. The identification of a valid therapy is delayed by the need of maintaining physiological MeCP2 levels and by the limited comprehension of its roles. ...
ORGANISM(S): Mus musculus 
2024-08-27 | E-MTAB-14403 | biostudies-arrayexpress
TranscriptomicsEffect of Tcf7l2 Knockout in the development and identity of Mouse brain Thalamus at embryonic stage E18.5 and P60
The thalamus of the brain acts as a relay station; taking inputs from several parts of the brain and then sending the information to the cortex and vice versa. It is also the structure know to affected in several brain developmental disorders such as schizophrenia, autism spectrum disorders, bipolar...
ORGANISM(S): Mus musculus 
2020-02-10 | E-MTAB-8755 | biostudies-arrayexpress
TranscriptomicsExpression data from postnatal mouse brain regions of Ts1Cje and disomic C57BL/6 mice.
The Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16 (MMU16), which is partially homologous to human chromosome 21. The mouse model develops various neuropathological features identified in DS individuals. We analysed the effect of partial triplication of the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-49050 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of purified populations of normal human breast luminal and myoepithelial cells
Purified populations of normal human breast luminal and myoepithelial cells were compared with cDNA microarray analysis.
ORGANISM(S): Homo sapiens 
2004-05-04 | E-MEXP-36 | biostudies-arrayexpress
TranscriptomicsBasal expression in daDREAM transgenic mouse hippocampus
Changes in nuclear Ca2+ homeostasis activate specific gene expression programs and are central to the acquisition and the plastic storage of memories. DREAM /KChIP proteins form heterotetramers that bind DNA and repress transcription in a Ca2+-dependent manner. Single ablation of one member of the D...
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-17844 | biostudies-arrayexpress
GenomicsModulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs epigenetic reprogramming
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes deregulated by specific combinations of these EBNAs thr...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-47629 | biostudies-arrayexpress
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