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2-methoxyestradiol (2ME2) induces mammary gland differentiation through amphiregulin-EGFR mediated signaling: molecular distinctions from the mammary gland of pregnant mice.High levels of 2ME2 are observed in the late stages of pregnancy. We investigated the role of 2ME2 on normal mammary gland de...
ORGANISM(S): Mus musculus 
Amniotic Epithelial Cells (AECs) exhibit paracrine immunoregulatory functions, however the effectors within their extracellular vesicles (EVs) are poorly defined. Using label-free proteomics and genetic approaches, we profiled the secretome of ovine AECs under basal and lipopolysaccharide (LPS)-mimi...
ORGANISM(S): Ovis aries 
2026-07-18 | PXD074552 | Pride
Radiation-induced amphiregulin drives tumor metastases
Cellular senescence is an irreversible growth arrest with a highly dynamic secretome, termed the senescence-associated secretory phenotype (SASP). Senescence has been implicated in somatic reprogramming to pluripotency. The cell-intrinsic proliferation arrest is a barrier for reprogramming, whereas ...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-28 | PXD028590 | Pride
Radiation-induced amphiregulin drives tumor metastasis
Transcriptional profiling of transgenic mice specifically expressing amphiregulin in white adipose tissues. The objective of this study is to explore gene expression profiles of adipose tissues in response to amphiregulin overexpression.
ORGANISM(S): Mus musculus 
2017-09-15 | GSE103875 | GEO
Engineered amphiregulin promotes tissue healing via multiple mechanisms following acute injury
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