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Murine pancreatic beta cell line MIN6 was growth at two different concentrations of glucose (22,2 and 5,5 mM of glucose), 37ºC, 5% CO2 and was treated at four different concentrations of human amylin (0, 1, 10 and 20 uM) during three different times (2, 12 and 24 hours)
ORGANISM(S): Mus musculus 
RNAseq data of frontal cortex of Sprague Dawley rats expressing rat amylin (WT), human amylin (HIP), and rat amylin knock-out (AKO) rats
Receptor activity-modifying proteins (RAMPs) regulate the pharmacology, trafficking, and signaling of class B1 G protein-coupled receptors (GPCRs). The calcitonin receptor (CTR) interacts with each of the three RAMPs to form amylin receptors (AMYRs), which display distinct ligand preferences and sig...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD068848 | Pride
Amyloidogenic peptides are therapeutic in EAE, reducing systemic levels of IL6, TNF, and INFg. The fibrils are bound and endocytosed in peritoneal MFs and B1a cells. Differential gene expression was used to further understand the process. Groups of three female C57BL/6 mice were injected with 10ug o...
ORGANISM(S): Mus musculus 
To investigate the effect of pancreatic human amylin protein on the gene expression profiles of the brain
ORGANISM(S): Rattus norvegicus 
2022-12-25 | GSE221450 | GEO
Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3
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