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MetabolomicsUsing an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein
INTRODUCTION: The pathogenicity at differing points along the aggregation pathway of many fibril-forming proteins associated with neurodegenerative diseases is unclear. Understanding the effect of different aggregation states of these proteins on cellular processes is essential to enhance understand...
2018-06-11 | MTBLS455 | MetaboLights
MetabolomicsAnalyzing nicotine action against amyloid toxicity by NMR-pharmacometabolomics: an exploratory study

Alzheimer's disease (AD) is the primary neurodegenerative disease spread worldwide. One of the main histopathological hallmarks of AD is amyloid plaque deposition in the brain. Despite some epidemiological studies demonstrating that cigarette smoke is a factor in predisposing people to AD, nicoti...

2026-06-26 | MTBLS12706 | MetaboLights
TranscriptomicsTranscription profiling of human cholinergic SN56.B5.G4 cells treated with beta-amyloid or hydrogen peroxide
Effect of beta-Amyloid and oxidative stress on gene expression in cholinergic SN56.B5.G4-cells
ORGANISM(S): Mus musculus 
2005-01-01 | E-MEXP-710 | biostudies-arrayexpress
TranscriptomicsModulation of gene expression by complement protein C1q in amyloid-beta injured neurons
Complement protein C1q is induced after injury in the brain and during Alzheimer's disease and has been shown to protect against amyloid-beta induced neuronal death. In this study, we used microarray approach to identify the pathways modulated by C1q that are associated with neuroprotection. Immatur...
ORGANISM(S): Rattus norvegicus 
2012-12-21 | E-GEOD-28886 | biostudies-arrayexpress
ProteomicsHigh-Throughput Screening of Amyloid Inhibitors via Covalent-Labeling Mass Spectrometry
MS spectra of DEPC modifications on beta-2-microglobulin (b2m) residues under amyloid-forming conditions, with or without 4-hydroxythalidomide.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-25 | MSV000098322 | MassIVE
MetabolomicsAPOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge (Part 3 of 3)
Not available
ORGANISM(S): Mus musculus 
ST002453 | MetabolomicsWorkbench
MetabolomicsAPOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge (Part 2 of 3)
Not available
ORGANISM(S): Mus musculus 
ST002451 | MetabolomicsWorkbench
MetabolomicsAPOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge (Part 1 of 3)
Not available
ORGANISM(S): Mus musculus 
ST002450 | MetabolomicsWorkbench
ProteomicsMajor Proteomic Changes Associated with Amyloid Induced Biofilm Formation in Pseudomonas aeruginosa PAO1
The newly identified functional amyloids in Pseudomonas (Fap) are associated with increased aggregation and biofilm formation in the opportunistic pathogen P. aeruginosa. However, whether this phenomenon can be simply ascribed to the mechanical properties of the amyloid fibrils remains...
ORGANISM(S): Pseudomonas Aeruginosa Pao1 (ncbitaxon:208964) 
MSV000082917 | MassIVE
TranscriptomicsComparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex
The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse pr...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25926 | biostudies-arrayexpress
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