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MetabolomicsThe transition from winter to spring has an impact on the airway metabolome profile of asthmatic horses

Equine asthma is a chronic, non-infectious inflammatory disease of the lower airways in horses, classified as mild to moderate (MEA) or severe (SEA). Its pathogenesis is not fully understood and is influenced by environmental and seasonal factors. In this cross-sectional study, seasonal effects o...

2026-03-23 | MTBLS13953 | MetaboLights
MetabolomicsPTER is an N-acetyltaurine hydrolase that regulates feeding and obesity

Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans1-3. In endogenous taurine metabolism, dedicated enzymes are involved in biosynthesis of taurine from cysteine as well as the downstream metabolism of secondary taurine metabolites4,5. One such ta...

2024-09-11 | MTBLS10408 | MetaboLights
TranscriptomicsGene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan
In patients with advanced colorectal cancer, leucovorin, fluorouracil, and irinotecan (FOLFIRI) is considered as one of the reference first-line treatments. However, only about half of treated patients respond to this regimen, and there is no clinically useful marker that predicts response. A major ...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-62080 | biostudies-arrayexpress
UnknownResponse Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.
Not available
S-EPMC5498638 | biostudies-literature
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
UnknownFOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression.
Not available
S-EPMC6365533 | biostudies-literature
ProteomicsReducing Dietary Protein Enhances the Anti-tumor Effects of Chemotherapy
Diet is believed to be an important mediator of oncogenesis and response to anti-cancer therapies, although, no evidence-based dietary guidelines exist for patients with cancer. Limiting protein intake can suppress tumor growth by both inducing nutrient stress and enhancing anti-tumor immunity. Howe...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-07 | PXD052110 | Pride
Cancer Cgas-sting Diet Chemotherapy 5-fu 
TranscriptomicsTranscription profiling of rectal adenocarcinomas biopsied before and after pre-operative short-course radiotherapy or 5-flurouracil-based chemoradiotherapy
The molecular mechanisms of clinical response or resistance to therapy were evaluated in colorectal cancer patients in a prospective biomarker discovery project. Rectal adenocarcinomas, biopsied before (diagnostic biopsy) and after (surgical resection) pre-operative short-course radiotherapy [RT] or...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-MEXP-1901 | biostudies-arrayexpress
UnknownWnt pathway is involved in 5-FU drug resistance of colorectal cancer cells.
Not available
S-EPMC6093888 | biostudies-literature
UnknownMicrocurrent stimulation induces cell death in p53-mutant and 5-FU-resistant breast cancer.
Not available
S-EPMC12301737 | biostudies-literature
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