Cgas-sting - OmicsDI

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Laboratory Head Walter and Eliza Hall Institute of Medical Research 1G Royal Parade, Parkville, AUS 3052 (1)

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Lily polysaccharides alleviate colitis through the microbiota/N8AS/cGAS-STING signaling axis

With the rising incidence of IBD and limitations of current therapies, novel strategies are urgently needed. Recent studies have highlighted natural products in colitis treatment. Here, we investigated the therapeutic effects and mechanisms of lily polysaccharides (LP) in DSS-induced ulcerative c...

2025-09-29 | MTBLS13064 | MetaboLights

Deposition of onco-histone H3.3-G34W leads to DNA repair deficiency and activates cGAS/STING-mediated immune responses

Mutations in histone H3.3-encoding genes causing mutant histone tails are associated with specific cancers such as pediatric glioblastomas (H3.3-G34R/V) and giant cell tumor of the bone (H3.3-G34W). The mechanisms by which these mutations promote malignancy are not completely understood. Here we sho...

ORGANISM(S): Homo sapiens (Human)

2025-04-08 | PXD047223 | Pride

cGAS/STING drives ageing-related inflammation and neurodegeneration I

PRJNA981207 | ENA

CK1α suppresses autoimmunity by restraining the cGAS-STING signaling

PRJNA940749 | ENA

cGAS/STING drives ageing-related inflammation and neurodegeneration IV

PRJNA981209 | ENA

cGAS/STING drives ageing-related inflammation and neurodegeneration III

PRJNA981210 | ENA

DNA-Protein Crosslinks Promote cGAS-STING-driven Premature Aging and Embryonic Lethality

DNA-protein crosslinks (DPCs) are severe DNA lesions that disrupt replication, transcription, and genome stability. However, their role in development and aging remains poorly understood. Here, we show that impaired SPRTN function, a metalloprotease essential for DPC repair during replication and mi...

ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human)

2025-09-30 | PXD051378 | Pride

Innate immunity Pyroptosis. Cgas-sting Mitosis Interferon Dpcs Sprtn Embryonic lethality

cGAS/STING drives ageing-related inflammation and neurodegeneration II

PRJNA981208 | ENA

cGAS-STING Pathway Mediation in Osteoclast Function and Bone Fracture Healing

PRJNA1328658 | ENA

The gene expression profiling in the brain of cGAS or STING deficiency mice

PRJNA989046 | ENA

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