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ProteomicsDeposition of onco-histone H3.3-G34W leads to DNA repair deficiency and activates cGAS/STING-mediated immune responses
Mutations in histone H3.3-encoding genes causing mutant histone tails are associated with specific cancers such as pediatric glioblastomas (H3.3-G34R/V) and giant cell tumor of the bone (H3.3-G34W). The mechanisms by which these mutations promote malignancy are not completely understood. Here we sho...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD047223 | Pride
H3.3 Onco-histone Dna repair Immune response G34w Cgas/sting 
UnknownGenistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells.
Not available
S-EPMC3960620 | biostudies-literature
UnknownChemical catalyst manipulating cancer epigenome and transcription.
Not available
S-EPMC11760346 | biostudies-literature
TranscriptomicsIncorporating histone H2B variants into chromatin modifies chromatin accessibility to induce the epithelial-to-mesenchymal transition in breast cancer [RNA]
Histones scaffold genomic DNA and regulate access to the transcriptional machinery. However, naturally occurring histone variants can alter histone-DNA interactions, DNA and histone modifications, and the chromatin interactome. Hence, alterations in histone variant deposition can disrupt chromatin, ...
ORGANISM(S): Homo sapiens 
2026-02-11 | GSE285391 | GEO
GenomicsIncorporating histone H2B variants into chromatin modifies chromatin accessibility to induce the epithelial-to-mesenchymal transition in breast cancer [CUT&RUN]
Histones scaffold genomic DNA and regulate access to the transcriptional machinery. However, naturally occurring histone variants can alter histone-DNA interactions, DNA and histone modifications, and the chromatin interactome. Hence, alterations in histone variant deposition can disrupt chromatin, ...
ORGANISM(S): Homo sapiens 
2026-02-11 | GSE285390 | GEO
GenomicsIncorporating histone H2B variants into chromatin modifies chromatin accessibility to induce the epithelial-to-mesenchymal transition in breast cancer [ATAC-seq]
Histones scaffold genomic DNA and regulate access to the transcriptional machinery. However, naturally occurring histone variants can alter histone-DNA interactions, DNA and histone modifications, and the chromatin interactome. Hence, alterations in histone variant deposition can disrupt chromatin, ...
ORGANISM(S): Homo sapiens 
2026-02-11 | GSE285389 | GEO
UnknownSingle amino-acid differences define H2B variants and modify chromatin accessibility to induce EMT in breast cancer.
Not available
S-EPMC12867764 | biostudies-literature
GenomicsThe Growth factor independence 1 (GFI1) 36N variant predisposes to Acute Myeloid Leukemia (AML) by inducing epigenetic changes at the Hoxa9 locus
GFI136N is a coding Single Nucleotide Polymorphism (SNP) in the gene GFI1 that increases the risk for Acute myeloid leukemia (AML) by 60%. It is present in 3-5% of Caucasians and has a prevalence of 12% among AML patients. We generated knockin mice expressing either the human GFI136N variant or the ...
ORGANISM(S): Mus musculus 
2012-12-04 | E-GEOD-31657 | biostudies-arrayexpress
UnknownThe Lipid Metabolism as Target and Modulator of BOLD-100 Anticancer Activity: Crosstalk with Histone Acetylation.
Not available
S-EPMC10646284 | biostudies-literature
UnknownSmall-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth.
Not available
S-EPMC8344022 | biostudies-literature
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