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MetabolomicsLily polysaccharides alleviate colitis through the microbiota/N8AS/cGAS-STING signaling axis

With the rising incidence of IBD and limitations of current therapies, novel strategies are urgently needed. Recent studies have highlighted natural products in colitis treatment. Here, we investigated the therapeutic effects and mechanisms of lily polysaccharides (LP) in DSS-induced ulcerative c...

2025-09-29 | MTBLS13064 | MetaboLights
ProteomicsIntracellular bacteria engage a novel STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling
The innate immune system is crucial for eventual control of infections, but may also contribute to pathology. Listeria monocytogenes is an intracellular gram-positive bacteria and a major cause of food-borne disease. However, important knowledge on the interactions between L. monocytogenes and the i...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-20 | PXD012135 | Pride
Phosphoproteomics Sting Cgas Intracellular bacteria Nucleic acid sensing 
ProteomicsThe Kinase CK1a coordinates Initiation and Termination of the cGAS-STING Pathway
The cGAS-STING pathway is an evolutionarily conserved antimicrobial defense mechanism that senses cytosolic DNA to trigger innate immune responses. cGAS and STING play dual roles in tumorigenesis, promoting antitumor immunity and cell death while fueling tumor growth and metastasis. However, the mec...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD063855 | Pride
Biotin Apex Lc-ms Cgas/ting Ap-ms Ck1-alpha 
ProteomicsThe Kinase CK1a coordinates Initiation and Termination of the cGAS-STING Pathway. Comparative proteomic analysis of CK1a partners.
The cGAS-STING pathway is an evolutionarily conserved antimicrobial defense mechanism that senses cytosolic DNA to trigger innate immune responses. cGAS and STING play dual roles in tumorigenesis, promoting antitumor immunity and cell death while fueling tumor growth and metastasis. However, the mec...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD066276 | Pride
Innate immunity Sting Cgas Csnk1a1 Dna sensing 
ProteomicsThe Kinase CK1a coordinates Initiation and Termination of the cGAS-STING Pathway. Comparative proteomic analysis of WT and KO CK1a cell lines.
The cGAS-STING pathway is an evolutionarily conserved antimicrobial defense mechanism that senses cytosolic DNA to trigger innate immune responses. cGAS and STING play dual roles in tumorigenesis, promoting antitumor immunity and cell death while fueling tumor growth and metastasis. However, the mec...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD066072 | Pride
Innate immunity Sting Cgas Csnk1a1 Dna sensing 
ProteomicsDeposition of onco-histone H3.3-G34W leads to DNA repair deficiency and activates cGAS/STING-mediated immune responses
Mutations in histone H3.3-encoding genes causing mutant histone tails are associated with specific cancers such as pediatric glioblastomas (H3.3-G34R/V) and giant cell tumor of the bone (H3.3-G34W). The mechanisms by which these mutations promote malignancy are not completely understood. Here we sho...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD047223 | Pride
H3.3 Onco-histone Dna repair Immune response G34w Cgas/sting 
GenomicscGAS/STING drives ageing-related inflammation and neurodegeneration I
cGAS/STING drives ageing-related inflammation and neurodegeneration I
PRJNA981207 | ENA
GenomicsCK1α suppresses autoimmunity by restraining the cGAS-STING signaling
CK1α suppresses autoimmunity by restraining the cGAS-STING signaling
PRJNA940749 | ENA
GenomicscGAS/STING drives ageing-related inflammation and neurodegeneration IV
cGAS/STING drives ageing-related inflammation and neurodegeneration IV
PRJNA981209 | ENA
GenomicscGAS/STING drives ageing-related inflammation and neurodegeneration III
cGAS/STING drives ageing-related inflammation and neurodegeneration III
PRJNA981210 | ENA
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