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MetabolomicsFunctional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction

Metabolic flexibility is key to survival and growth in all living organisms. In mammals, the pathways supporting cell proliferation in nutrient-limiting conditions have not been fully elucidated, although certain tumors display metabolic dependencies that can be targeted for therapy. He...

2026-02-02 | MTBLS13799 | MetaboLights
TranscriptomicsEffect of biotin deficiency on gene expression in Aravbidopsis leaves
In addition to its essential metabolic functions biotin is suggested a critical role in regulating gene expression. The first committed enzyme in biotin biosynthesis in Arabidopsis, 7-keto-8-aminopelargonic acid synthase is encoded by At5g04620 (BIO4). We isolated a novel T-DNA insertion mutant of B...
ORGANISM(S): Arabidopsis thaliana 
2011-12-22 | E-GEOD-26631 | biostudies-arrayexpress
TranscriptomicsCatabolite repression of phosphoenolpyruvate carboxykinase by a zinc finger protein under biotin- and pyruvate carboxylase-deficient conditions in Pichia pastoris
We have identified a methanol- and biotin-starvation-inducible zinc finger protein named ROP [repressor of phosphoenolpyruvate carboxykinase (PEPCK)] in the methylotrophic yeast Pichia pastoris. When P.pastoris strain GS115 (wild-type, WT) is cultured in biotin-deficient, glucose ammonium (Bio-) ...
ORGANISM(S): Pichia pastoris 
2011-10-13 | E-GEOD-32948 | biostudies-arrayexpress
ProteomicsThiol-cleavable Biotin for Chemical and Enzymatic Biotinylation and its Application to Mitochondrial TurboID Proteomics
Protein biotinylation via chemical or enzymatic reactions is often coupled with streptavidin-based enrichment and on-beads digestion in numerous biological applications. However, the popular on-beads digestion method faces major challenges of streptavidin contamination, the lost information of bioti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-21 | MSV000087256 | MassIVE
Genomicsmetacardis-biotin-nanopore
Decreased microbial load in severe obesity links impaired gut microbiota biotin metabolism to host biotin status
PRJEB42966 | ENA
Genomicsmetacardis-biotin-16s
Decreased microbial load in severe obesity links impaired gut microbiota biotin metabolism to host biotin status
PRJEB42967 | ENA
ProteomicsBiotin proximity tagging favors unfolded proteins and enables the study of intrinsically disordered regions
Intrinsically Disordered Regions (IDRs) are enriched in disease-linked proteins known to have multiple post-translational modifications, but there is limited in vivo information about how locally unfolded protein regions contribute to biological functions. We reasoned that IDRs should be more access...
ORGANISM(S): Escherichia coli 
2020-01-29 | PXD016422 | Pride
Lc-sps-ms3 E. coli H. sapiens Idr Biotin 
ProteomicsBiotin starvation in yeast - Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p
yeast cells were starved for biotin and the proteome and acetylome changes were analyzed by quantitative mass spectrometry
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-12-13 | PXD002168 | Pride
Yeast cells starved for biotin 
GenomicsBiotin deficiency on the mouse gut microbiome
Biotin deficiency on the mouse gut microbiome Raw sequence reads
PRJNA904819 | ENA
ProteomicsHeart surfaceome profiling using biotin capture
Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling, and cellular phenotyping. Understanding the surfaceome of complex tissues including the heart is essential to investigate membrane composition and function in physiol...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000095912 | MassIVE
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