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TranscriptomicsSynthetic cationic peptide IDR-1018 modulates human macrophage differentiation
Synthetic, innate defense regulators (IDR) peptides, designed based on natural host defenses peptides, have enhanced immunomodulatory activities and reduced toxicity leading to protection in infection and inflammation models that is dependent on macrophages/monocytes. Here we measured the effect of ...
ORGANISM(S): Homo sapiens 
2013-10-16 | E-GEOD-40131 | biostudies-arrayexpress
TranscriptomicsRescue Of Dysfunctional Autophagy By Peptide IDR-1018 Attenuates Hyperinflammatory Phenotype Of Cystic Fibrosis Cells (RNA-seq)
Genome-wide gene expression was measured in peripheral blood mononuclear cells (PBMCs) from patients with cystic fibrosis (CF) after treatment in vitro with the flagellin protein fliC, and/or synthetic peptide IDR-1018 to assess patterns of gene expression. The patterns of gene expression suggest th...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-35394 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD14+ monocytes treated with innate defence regulator peptide IDR-1 in the presence/absence of lipopolyssacharide
Effect of peptide IDR-1 on CD14+ human monocytes. >br< >br< Effect of peptide IDR-1 on LPS-induced responses in CD14+ human monocytes.>br< >br< Human peripheral blood mononuclear cells (PBMC) were treated with innate defence regulator peptide IDR-1 in the presence and absence of LPS (purified from P...
ORGANISM(S): Homo sapiens 
2007-04-10 | E-FPMI-8 | biostudies-arrayexpress
TranscriptomicsIDR-1018 treatment of mice infected with Plasmodium berghei, spleen and brain expression data
Severe malaria encompasses a range of syndromes manifesting systemically or in diverse organs. These are believed to represent the end-stage processes of local parasite sequestration and inflammatory cascades. Classical anti-malarial drugs target parasites only. In treatment of severe disease, adjun...
ORGANISM(S): Mus musculus 
2012-04-08 | E-GEOD-32007 | biostudies-arrayexpress
GenomicsWT and RNE∆IDR mRNA half-life profiling in Sinorhizobium meliloti.
WT and RNE∆IDR mRNA half-life profiling in Sinorhizobium meliloti.
PRJNA1055090 | ENA
GenomicsWAGO-1/3 IDR processing
Effects of IDR processing in WAGO-1 and WAGO-3 on small RNA binding and overall small RNA landscapes
PRJEB95103 | ENA
UnknownSynthetic cationic peptide IDR-1018 modulates human macrophage differentiation.
Not available
S-EPMC3538731 | biostudies-literature
GenomicsEffect of over expression of MED13 IDR in human osteosarcoma U2OS cell line
Effect of over expression of MED13 IDR in human osteosarcoma U2OS cell line
PRJNA1054158 | ENA
GenomicsTranscriptomic profiling of IDR CAR-T cells in the CD19 cancer model.
Transcriptomic profiling of IDR CAR-T cells in the CD19 cancer model.
PRJNA1135885 | ENA
TranscriptomicsSynthetic cationic peptide IDR-1018 modulates human macrophage differentiation
Synthetic, innate defense regulators (IDR) peptides, designed based on natural host defenses peptides, have enhanced immunomodulatory activities and reduced toxicity leading to protection in infection and inflammation models that is dependent on macrophages/monocytes. Here we measured the effect of ...
ORGANISM(S): Homo sapiens 
2013-10-16 | GSE40131 | GEO
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